Fig. 3

Flow charts of the cell proliferation simulation. The left chart shows the main process and the right chart shows the cellular automata process. One cycle of the process is 10 min of virtual cell culture. There are two events, namely movement and division, in the cellular automata process. The movement event is started according to the P _mot , which is determined by the cell motility parameter mot, and terminated according to the P _motesc , which is determined by the effect of cell–cell adhesion (parameter a) with surrounding cells (the parameter is P _su ). The cell division event is started according to the P _div , which is determined by the cell doubling time t _d , and terminated according to the P _ci , which is determined by the effect of surrounding cells