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Table 1 MICs of chlorhexidine against the clinical and ATCC strains of P. aeruginosa and S. aureus obtained in the absence and presence of CCCP or reserpine

From: Development of an accumulation assay and evaluation of the effects of efflux pump inhibitors on the retention of chlorhexidine digluconate in Pseudomonas aeruginosa and Staphylococcus aureus

Determined MIC

P. aeruginosa clinical strain (µg/ml)

P. aeruginosa clinical strain

S. aureus clinical strain

S. aureus ATCC strain

Chlorhexidine only

6.3

6.3

6.3

6.3

Chlorhexidine + CCCP

6.3

6.3

<0.1

<0.1

Chlorhexidine + reserpine

3.2

3.2

3.2

6.3

  1. Italics indicates a decrease in the MIC of chlorhexidine in the presence of an EPI