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Table 3 Predicted KEGG orthologs with significant differences in relative abundance between infants with bronchiolitis and healthy controls

From: Sphingolipid metabolism potential in fecal microbiome and bronchiolitis in infants: a case–control study

KEGG orthologs

Mean abundance in cases (%)

Mean abundance in controls (%)

Raw P value

FDR corrected q value

K00179; indolepyruvate ferredoxin oxidoreductase, alpha subunit [EC:1.2.7.8]

0.020

0.009

<0.001

0.026

K00180; indolepyruvate ferredoxin oxidoreductase, beta subunit [EC:1.2.7.8]

0.007

0.003

<0.001

0.028

K02489; two-component system, cell cycle sensor kinase and response regulator [EC:2.7.13.3]

0.004

0.002

0.001

0.038

K03319; divalent anion:Na+ symporter, DASS family

0.019

0.044

<0.001

0.028

K08082; two-component system, LytT family, sensor histidine kinase AlgZ [EC:2.7.13.3]

0.011

0.005

0.001

0.041

K08196; MFS transporter, AAHS family, cis, cis-muconate transporter

0.001

0.002

0.002

0.044

K10715; two-component system, sensor histidine kinase RpfC [EC:2.7.13.3]

0.009

0.005

0.001

0.036

K10916; two-component system, CAI-1 autoinducer sensor kinase/phosphatase CqsS [EC:2.7.13.3 3.1.3.-]

0.001

0.000

0.001

0.031

K11382; MFS transporter, OPA family, phosphoglycerate transporter protein

0.006

0.015

0.000

0.028

K11383; two-component system, NtrC family, sensor histidine kinase KinB [EC:2.7.13.3]

0.001

0.000

0.001

0.034

K11520; two-component system, OmpR family, manganese sensing sensor histidine kinase [EC:2.7.13.3]

0.001

0.000

0.000

0.028

K11527; two-component system, unclassified family, sensor histidine kinase and response regulator [EC:2.7.13.3]

0.023

0.011

0.001

0.038

K15850; two-component system, autoinducer 1 sensor kinase/phosphatase LuxN [EC:2.7.13.3 3.1.3.-]

0.001

0.000

<0.001

0.026

K15913; UDP-4-amino-4,6-dideoxy-N-acetyl-d-glucosamine 4-acetyltransferase [EC:2.3.1.-]

0.000

0.000

0.002

0.049

K16014; ATP-binding cassette, subfamily C, bacterial CydCD

0.005

0.010

0.002

0.042

K00176; 2-oxoglutarate ferredoxin oxidoreductase subunit delta [EC:1.2.7.3]

0.001

0.001

0.001

0.035

K00177; 2-oxoglutarate ferredoxin oxidoreductase subunit gamma [EC:1.2.7.3]

0.010

0.005

0.001

0.041

K00200; formylmethanofuran dehydrogenase subunit A [EC:1.2.99.5]

0.001

0.000

0.001

0.038

K00316; spermidine dehydrogenase [EC:1.5.99.6]

0.000

0.000

0.002

0.046

K00406; cytochrome c oxidase cbb3-type subunit III

0.002

0.004

0.001

0.030

K00436; hydrogen dehydrogenase [EC:1.12.1.2]

0.002

0.001

<0.001

0.023

K00824; d-alanine transaminase [EC:2.6.1.21]

0.004

0.008

0.002

0.045

K00832; aromatic-amino-acid transaminase [EC:2.6.1.57]

0.010

0.020

<0.001

0.026

K00856; adenosine kinase [EC:2.7.1.20]

0.002

0.001

0.001

0.034

K00908; Ca2+/calmodulin-dependent protein kinase [EC:2.7.11.17]

0.001

0.000

<0.001

0.023

K01235; alpha-glucuronidase [EC:3.2.1.139]

0.017

0.008

0.002

0.041

K01601; ribulose-bisphosphate carboxylase large chain [EC:4.1.1.39]

0.003

0.010

0.002

0.042

K01841; phosphoenolpyruvate phosphomutase [EC:5.4.2.9]

0.008

0.004

0.002

0.049

K01906; 6-carboxyhexanoate–CoA ligase [EC:6.2.1.14]

0.003

0.007

0.001

0.037

K01912; phenylacetate-CoA ligase [EC:6.2.1.30]

0.037

0.018

0.001

0.041

K02121; V-type H+ -transporting ATPase subunit E [EC:3.6.3.14]

0.010

0.005

<0.001

0.024

K02655; type IV pilus assembly protein PilE

0.002

0.005

<0.001

0.023

K03330; glutamyl-tRNA (Gln) amidotransferase subunit E [EC:6.3.5.7]

0.001

0.003

0.001

0.042

K03404; magnesium chelatase subunit D [EC:6.6.1.1]

0.007

0.019

0.002

0.046

K03756; putrescine:ornithine antiporter

0.007

0.016

<0.001

0.024

K04561; nitric oxide reductase subunit B [EC:1.7.2.5]

0.006

0.017

<0.001

0.026

K05586; bidirectional [NiFe] hydrogenase diaphorase subunit [EC:1.6.5.3]

0.001

0.000

0.001

0.032

K05588; bidirectional [NiFe] hydrogenase diaphorase subunit [EC:1.6.5.3]

0.001

0.000

0.002

0.043

K05589; cell division protein FtsB

0.002

0.003

<0.001

0.024

K05989; alpha-l-rhamnosidase [EC:3.2.1.40]

0.056

0.028

0.002

0.045

K06138; pyrroloquinoline quinone biosynthesis protein D

0.001

0.000

0.001

0.034

K07326; hemolysin activation/secretion protein

0.001

0.003

<0.001

0.026

K07536; 2-ketocyclohexanecarboxyl-CoA hydrolase [EC:3.1.2.-]

0.001

0.002

0.001

0.041

K09002; hypothetical protein

0.006

0.018

0.001

0.041

K09020; ureidoacrylate peracid hydrolase [EC:3.5.1.110]

0.002

0.003

0.001

0.031

K09162; hypothetical protein

0.003

0.008

0.001

0.034

K09459; phosphonopyruvate decarboxylase [EC:4.1.1.82]

0.005

0.003

0.003

0.050

K09477; citrate:succinate antiporter

0.008

0.016

0.001

0.034

K09758; aspartate 4-decarboxylase [EC:4.1.1.12]

0.015

0.007

<0.001

0.026

K09800; hypothetical protein

0.025

0.053

<0.001

0.026

K09824; hypothetical protein

0.007

0.014

<0.001

0.026

K10960; geranylgeranyl reductase [EC:1.3.1.83]

0.001

0.000

<0.001

0.027

K10974; cytosine permease

0.007

0.016

<0.001

0.026

K11016; hemolysin

0.001

0.002

0.001

0.029

K11106; l-tartrate/succinate antiporter

0.009

0.020

<0.001

0.026

K11607; manganese/iron transport system ATP-binding protein

0.004

0.009

<0.001

0.022

K11707; manganese/zinc/iron transport system substrate-binding protein

0.003

0.007

0.001

0.041

K11708; manganese/zinc/iron transport system permease protein

0.003

0.007

0.002

0.042

K11709; manganese/zinc/iron transport system permease protein

0.004

0.008

0.001

0.034

K11719; lipopolysaccharide export system protein LptC

0.003

0.007

<0.001

0.023

K11931; biofilm PGA synthesis lipoprotein PgaB [EC:3.-.-.-]

0.008

0.016

<0.001

0.028

K12341; adhesin YadA

0.005

0.012

0.001

0.041

K12681; pertactin

0.001

0.002

0.002

0.041

K12982; heptosyltransferase I [EC:2.4.-.-]

0.001

0.002

<0.001

0.028

K13256; protein PsiE

0.003

0.006

<0.001

0.029

K13498; indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase [EC:4.1.1.48 5.3.1.24]

0.008

0.017

<0.001

0.022

K13818; molybdopterin-guanine dinucleotide biosynthesis protein

0.001

0.003

0.001

0.029

K14448; (2S)-methylsuccinyl-CoA dehydrogenase

0.002

0.001

0.001

0.032

K14564; nucleolar protein 56

0.001

0.000

0.002

0.043

K14665; amidohydrolase [EC:3.5.1.-]

0.002

0.004

0.001

0.031

K15125; filamentous hemagglutinin

0.032

0.092

0.000

0.024

K15669; d-glycero-alpha-d-manno-heptose 1-phosphate guanylyltransferase [EC:2.7.7.71]

0.002

0.001

0.001

0.031

K15905; nitrite oxidoreductase alpha subunit

0.001

0.003

0.001

0.041

K16201; dipeptide transport system permease protein

0.001

0.003

0.002

0.045

  1. Of 6402 KEGG orthologs surveyed, the relative abundances of 319 genes were significantly different (FDR, q < 0.05) between infants with bronchiolitis and healthy controls. Of these, 74 orthologs with a ratio of abundance >2.0 are displayed
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BMC Research Notes

ISSN: 1756-0500

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