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Table 3 Predicted KEGG orthologs with significant differences in relative abundance between infants with bronchiolitis and healthy controls

From: Sphingolipid metabolism potential in fecal microbiome and bronchiolitis in infants: a case–control study

KEGG orthologs Mean abundance in cases (%) Mean abundance in controls (%) Raw P value FDR corrected q value
K00179; indolepyruvate ferredoxin oxidoreductase, alpha subunit [EC:1.2.7.8] 0.020 0.009 <0.001 0.026
K00180; indolepyruvate ferredoxin oxidoreductase, beta subunit [EC:1.2.7.8] 0.007 0.003 <0.001 0.028
K02489; two-component system, cell cycle sensor kinase and response regulator [EC:2.7.13.3] 0.004 0.002 0.001 0.038
K03319; divalent anion:Na+ symporter, DASS family 0.019 0.044 <0.001 0.028
K08082; two-component system, LytT family, sensor histidine kinase AlgZ [EC:2.7.13.3] 0.011 0.005 0.001 0.041
K08196; MFS transporter, AAHS family, cis, cis-muconate transporter 0.001 0.002 0.002 0.044
K10715; two-component system, sensor histidine kinase RpfC [EC:2.7.13.3] 0.009 0.005 0.001 0.036
K10916; two-component system, CAI-1 autoinducer sensor kinase/phosphatase CqsS [EC:2.7.13.3 3.1.3.-] 0.001 0.000 0.001 0.031
K11382; MFS transporter, OPA family, phosphoglycerate transporter protein 0.006 0.015 0.000 0.028
K11383; two-component system, NtrC family, sensor histidine kinase KinB [EC:2.7.13.3] 0.001 0.000 0.001 0.034
K11520; two-component system, OmpR family, manganese sensing sensor histidine kinase [EC:2.7.13.3] 0.001 0.000 0.000 0.028
K11527; two-component system, unclassified family, sensor histidine kinase and response regulator [EC:2.7.13.3] 0.023 0.011 0.001 0.038
K15850; two-component system, autoinducer 1 sensor kinase/phosphatase LuxN [EC:2.7.13.3 3.1.3.-] 0.001 0.000 <0.001 0.026
K15913; UDP-4-amino-4,6-dideoxy-N-acetyl-d-glucosamine 4-acetyltransferase [EC:2.3.1.-] 0.000 0.000 0.002 0.049
K16014; ATP-binding cassette, subfamily C, bacterial CydCD 0.005 0.010 0.002 0.042
K00176; 2-oxoglutarate ferredoxin oxidoreductase subunit delta [EC:1.2.7.3] 0.001 0.001 0.001 0.035
K00177; 2-oxoglutarate ferredoxin oxidoreductase subunit gamma [EC:1.2.7.3] 0.010 0.005 0.001 0.041
K00200; formylmethanofuran dehydrogenase subunit A [EC:1.2.99.5] 0.001 0.000 0.001 0.038
K00316; spermidine dehydrogenase [EC:1.5.99.6] 0.000 0.000 0.002 0.046
K00406; cytochrome c oxidase cbb3-type subunit III 0.002 0.004 0.001 0.030
K00436; hydrogen dehydrogenase [EC:1.12.1.2] 0.002 0.001 <0.001 0.023
K00824; d-alanine transaminase [EC:2.6.1.21] 0.004 0.008 0.002 0.045
K00832; aromatic-amino-acid transaminase [EC:2.6.1.57] 0.010 0.020 <0.001 0.026
K00856; adenosine kinase [EC:2.7.1.20] 0.002 0.001 0.001 0.034
K00908; Ca2+/calmodulin-dependent protein kinase [EC:2.7.11.17] 0.001 0.000 <0.001 0.023
K01235; alpha-glucuronidase [EC:3.2.1.139] 0.017 0.008 0.002 0.041
K01601; ribulose-bisphosphate carboxylase large chain [EC:4.1.1.39] 0.003 0.010 0.002 0.042
K01841; phosphoenolpyruvate phosphomutase [EC:5.4.2.9] 0.008 0.004 0.002 0.049
K01906; 6-carboxyhexanoate–CoA ligase [EC:6.2.1.14] 0.003 0.007 0.001 0.037
K01912; phenylacetate-CoA ligase [EC:6.2.1.30] 0.037 0.018 0.001 0.041
K02121; V-type H+ -transporting ATPase subunit E [EC:3.6.3.14] 0.010 0.005 <0.001 0.024
K02655; type IV pilus assembly protein PilE 0.002 0.005 <0.001 0.023
K03330; glutamyl-tRNA (Gln) amidotransferase subunit E [EC:6.3.5.7] 0.001 0.003 0.001 0.042
K03404; magnesium chelatase subunit D [EC:6.6.1.1] 0.007 0.019 0.002 0.046
K03756; putrescine:ornithine antiporter 0.007 0.016 <0.001 0.024
K04561; nitric oxide reductase subunit B [EC:1.7.2.5] 0.006 0.017 <0.001 0.026
K05586; bidirectional [NiFe] hydrogenase diaphorase subunit [EC:1.6.5.3] 0.001 0.000 0.001 0.032
K05588; bidirectional [NiFe] hydrogenase diaphorase subunit [EC:1.6.5.3] 0.001 0.000 0.002 0.043
K05589; cell division protein FtsB 0.002 0.003 <0.001 0.024
K05989; alpha-l-rhamnosidase [EC:3.2.1.40] 0.056 0.028 0.002 0.045
K06138; pyrroloquinoline quinone biosynthesis protein D 0.001 0.000 0.001 0.034
K07326; hemolysin activation/secretion protein 0.001 0.003 <0.001 0.026
K07536; 2-ketocyclohexanecarboxyl-CoA hydrolase [EC:3.1.2.-] 0.001 0.002 0.001 0.041
K09002; hypothetical protein 0.006 0.018 0.001 0.041
K09020; ureidoacrylate peracid hydrolase [EC:3.5.1.110] 0.002 0.003 0.001 0.031
K09162; hypothetical protein 0.003 0.008 0.001 0.034
K09459; phosphonopyruvate decarboxylase [EC:4.1.1.82] 0.005 0.003 0.003 0.050
K09477; citrate:succinate antiporter 0.008 0.016 0.001 0.034
K09758; aspartate 4-decarboxylase [EC:4.1.1.12] 0.015 0.007 <0.001 0.026
K09800; hypothetical protein 0.025 0.053 <0.001 0.026
K09824; hypothetical protein 0.007 0.014 <0.001 0.026
K10960; geranylgeranyl reductase [EC:1.3.1.83] 0.001 0.000 <0.001 0.027
K10974; cytosine permease 0.007 0.016 <0.001 0.026
K11016; hemolysin 0.001 0.002 0.001 0.029
K11106; l-tartrate/succinate antiporter 0.009 0.020 <0.001 0.026
K11607; manganese/iron transport system ATP-binding protein 0.004 0.009 <0.001 0.022
K11707; manganese/zinc/iron transport system substrate-binding protein 0.003 0.007 0.001 0.041
K11708; manganese/zinc/iron transport system permease protein 0.003 0.007 0.002 0.042
K11709; manganese/zinc/iron transport system permease protein 0.004 0.008 0.001 0.034
K11719; lipopolysaccharide export system protein LptC 0.003 0.007 <0.001 0.023
K11931; biofilm PGA synthesis lipoprotein PgaB [EC:3.-.-.-] 0.008 0.016 <0.001 0.028
K12341; adhesin YadA 0.005 0.012 0.001 0.041
K12681; pertactin 0.001 0.002 0.002 0.041
K12982; heptosyltransferase I [EC:2.4.-.-] 0.001 0.002 <0.001 0.028
K13256; protein PsiE 0.003 0.006 <0.001 0.029
K13498; indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase [EC:4.1.1.48 5.3.1.24] 0.008 0.017 <0.001 0.022
K13818; molybdopterin-guanine dinucleotide biosynthesis protein 0.001 0.003 0.001 0.029
K14448; (2S)-methylsuccinyl-CoA dehydrogenase 0.002 0.001 0.001 0.032
K14564; nucleolar protein 56 0.001 0.000 0.002 0.043
K14665; amidohydrolase [EC:3.5.1.-] 0.002 0.004 0.001 0.031
K15125; filamentous hemagglutinin 0.032 0.092 0.000 0.024
K15669; d-glycero-alpha-d-manno-heptose 1-phosphate guanylyltransferase [EC:2.7.7.71] 0.002 0.001 0.001 0.031
K15905; nitrite oxidoreductase alpha subunit 0.001 0.003 0.001 0.041
K16201; dipeptide transport system permease protein 0.001 0.003 0.002 0.045
  1. Of 6402 KEGG orthologs surveyed, the relative abundances of 319 genes were significantly different (FDR, q < 0.05) between infants with bronchiolitis and healthy controls. Of these, 74 orthologs with a ratio of abundance >2.0 are displayed