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Table 4 Predicted KEGG pathways with significant differences in relative abundance between infants with bronchiolitis and healthy controls

From: Sphingolipid metabolism potential in fecal microbiome and bronchiolitis in infants: a case–control study

KEGG pathway Difference in relative abundance Correlation with Bacteroides abundance
Mean abundance in cases (%) Mean abundance in controls (%) Raw P value FDR corrected q value Spearman’s rho P value
ko00051; fructose and mannose metabolism 1.691 1.447 0.001 0.043 0.55 <0.001
ko00052; galactose metabolism 1.473 1.298 0.004 0.035 0.66 <0.001
ko00140; steroid hormone biosynthesis 0.098 0.063 0.007 0.049 0.66 <0.001
ko00190; oxidative phosphorylation 1.332 1.215 0.005 0.041 0.41 <0.001
ko00311; penicillin and cephalosporin biosynthesis 0.068 0.060 0.001 0.041 0.44 <0.001
ko00450; selenocompound metabolism 0.626 0.703 0.001 0.046 −0.61 <0.001
ko00460; cyanoamino acid metabolism 0.280 0.222 0.004 0.037 0.82 <0.001
ko00472; d-arginine and d-ornithine metabolism 0.001 0.002 0.004 0.037 −0.52 <0.001
ko00480; glutathione metabolism 0.678 0.764 0.001 0.035 −0.49 <0.001
ko00511; other glycan degradation 1.198 0.910 0.002 0.035 0.72 <0.001
ko00520; amino sugar and nucleotide sugar metabolism 2.751 2.450 0.002 0.037 0.77 <0.001
ko00523; polyketide sugar unit biosynthesis 0.196 0.163 0.002 0.035 0.80 <0.001
ko00531; glycosaminoglycan degradation 0.256 0.152 0.005 0.044 0.73 <0.001
ko00532; glycosaminoglycan biosynthesis 0.035 0.026 0.001 0.048 0.72 <0.001
ko00591; linoleic acid metabolism 0.120 0.113 0.006 0.047 0.52 <0.001
ko00600; sphingolipid metabolism 0.489 0.351 0.003 0.034 0.77 <0.001
ko00603; glycosphingolipid biosynthesis 0.134 0.097 0.003 0.031 0.73 <0.001
ko00604; glycosphingolipid biosynthesis 0.061 0.039 0.006 0.048 0.74 <0.001
ko00642; Ethylbenzene degradation 0.084 0.075 0.002 0.034 0.25 0.001
ko00660; C5-branched dibasic acid metabolism 0.171 0.191 <0.001 0.028 −0.50 <0.001
ko00940; phenylpropanoid biosynthesis 0.213 0.163 0.006 0.048 0.81 <0.001
ko00944; flavone and flavonol biosynthesis 0.015 0.009 0.002 0.036 0.77 <0.001
ko03015; mRNA surveillance pathway 0.003 0.001 0.003 0.032 0.80 <0.001
ko04141; protein processing in endoplasmic reticulum 0.063 0.049 0.006 0.049 0.69 <0.001
ko04142; lysosome 0.310 0.194 0.006 0.047 0.76 <0.001
ko04210; apoptosis 0.043 0.025 0.002 0.030 0.69 <0.001
ko04612; antigen processing and presentation 0.014 0.010 0.002 0.031 0.58 <0.001
ko04621; NOD-like receptor signaling pathway 0.056 0.042 0.001 0.040 0.74 <0.001
ko04721; synaptic vesicle cycle 0.001 0.000 0.002 0.033 0.58 <0.001
ko04725; cholinergic synapse 0.002 0.005 0.003 0.031 −0.12 0.14
ko04914; progesterone-mediated oocyte maturation 0.014 0.010 0.002 0.033 0.58 <0.001
ko04930; type II diabetes mellitus 0.026 0.028 0.001 0.036 −0.47 <0.001
ko04962; vasopressin-regulated water reabsorption 0.001 0.000 0.002 0.036 0.58 <0.001
ko05110; vibrio cholerae infection 0.001 0.004 0.006 0.046 −0.41 <0.001
ko05133; pertussis 0.356 0.609 0.002 0.029 −0.24 0.03
ko05211; renal cell carcinoma 0.013 0.019 <0.001 0.028 −0.58 <0.001
ko05215; prostate cancer 0.016 0.011 0.002 0.037 0.63 <0.001
  1. Italics results are the pathways of interest (sphingolipid metabolic pathways)