Fig. 3

Effects of diet and exercise on markers of ribosome degradation. The effects of the intervention on USP10 protein levels (a) and G3BP1 protein levels (b) (both markers being critical for ribophagy), as well as EXOSC10 protein levels (c) and SKIV2L2 protein levels (d) (both markers being the TRAMP exosome rRNA degradation pathway). e Representative images of Western blotting targets. All data are presented as mean ± SD (n = 10–16 rats per group), group mean values are presented within each bar, 95% confidence intervals are presented in parentheses within each bar, and bars with different superscript letters indicate between-treatment differences (p < 0.05). O-CON OLETF rats consuming a control diet during weeks 20–32 and were not treadmill-trained, O-WD/SED OLETF rats consuming a Western diet during weeks 20–32 and were not treadmill-trained, O-WD/EX OLETF rats consuming a Western diet during weeks 20–32 and were treadmill-trained 5 days/week