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Table 4 Comparison of the two techniques during the IPP (20 min) based on pharmacokinetic and biochemical parameters

From: Surgical versus percutaneous isolated pelvic perfusion (IPP) for advanced melanoma: comparison in terms of melphalan pharmacokinetic pelvic bio-availability

Technique

Surgical

Percutaneous

MW

Median

IQR

Median

IQR

p value

Cmax perfused compartment (µg/ml)

8.8

(7.3 to 8.8)

7.4

(5.6 to 7.8)

0.346

Cmax perfused compartment/Cmax peripheric compartment

7.8

(6.2 to 8.4)

6.6

(5 to 7.5)

0.602

AUC0 to 20 perfused compartment/AUC0 to 20 peripheric compartment

7.9

(7.2 to 9.9)

5

(4 to 7.9)

0.209

pH extracorporeal circuit

7.39

(7.38 to 7.39)

7.38

(7.38 to 7.39)

0.656

pO2 extracorporeal circuit (mmHg)

29.41

(28.56 to 29.64)

29.64

(29.51 to 29.67)

0.248

  1. MW Mann–Whitney test, C max maximum plasma concentration, AUC 0 to 20 area under the plasma concentration curve (0 to 20 min)