Skip to main content

Table 4 Comparison of the two techniques during the IPP (20 min) based on pharmacokinetic and biochemical parameters

From: Surgical versus percutaneous isolated pelvic perfusion (IPP) for advanced melanoma: comparison in terms of melphalan pharmacokinetic pelvic bio-availability

Technique Surgical Percutaneous MW
Median IQR Median IQR p value
Cmax perfused compartment (µg/ml) 8.8 (7.3 to 8.8) 7.4 (5.6 to 7.8) 0.346
Cmax perfused compartment/Cmax peripheric compartment 7.8 (6.2 to 8.4) 6.6 (5 to 7.5) 0.602
AUC0 to 20 perfused compartment/AUC0 to 20 peripheric compartment 7.9 (7.2 to 9.9) 5 (4 to 7.9) 0.209
pH extracorporeal circuit 7.39 (7.38 to 7.39) 7.38 (7.38 to 7.39) 0.656
pO2 extracorporeal circuit (mmHg) 29.41 (28.56 to 29.64) 29.64 (29.51 to 29.67) 0.248
  1. MW Mann–Whitney test, C max maximum plasma concentration, AUC 0 to 20 area under the plasma concentration curve (0 to 20 min)