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Table 3 Toxicity of compounds used in the trial

From: Galleria mellonella (greater wax moth) larvae as a model for antibiotic susceptibility testing and acute toxicity trials

Compound

LD50 (mg/kg body weight)a

G. mellonella

Rat

Mouse

Intraperitoneal

Oral

Intraperitoneal

Oral

Intraperitoneal

Amsacrine

40

100

 

243

 

Chloroquine

125b

623

 

500

 

Ciprofloxacin

>2000

>2000

 

>2000

 

DMSO

100

14,500

 

7920

 

Doxorubicin

5.5

 

16

698

1.2

Etoposide

100

1784

58

215

 

Glucose

>2000

25,800

   

Novobiocin

100

3500

 

962

 

Sodium chloride

>2000

3000

 

4000

 

Streptomycin

300

430

 

430

 

Tetracycline

>2000

6443

318

2759

368

  1. aLD50 values determined in the test were compared to values available in Material Safety Data sheets provided with the compounds. Blank space indicates the data are not available
  2. bCompounds tested at >100 mg/Kg were initially tested in 50% DMSO (which is toxic to G. mellonella) and then re-tested at lower [DMSO]s such that the final [DMSO] was 10%