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Table 1 Selected characteristics of study sample

From: Associations of two-pore domain potassium channels and triple negative breast cancer subtype in The Cancer Genome Atlas: systematic evaluation of gene expression and methylation

Characteristic Gene expressiona Methylationb
N [%] N [%]
Total 959 [100] 767 [100]
Race
 nH white 592 [85.6] 471 [78.6]
 nH black 100 [14.5] 128 [21.4]
Age (years)
 >/=50 682 [73.3] 477 [71.3]
 <50 248 [26.7] 192 [28.7]
Menopausal status
 Post 653 [76.1] 497 [75]
 Pre 205 [23.9] 165 [25]
Stage
 I 160 [17.3] 126 [17.4]
 II 536 [58] 402 [55.4]
 III 213 [23.1] 188 [25.9]
 IV 15 [1.6] 10 [1.4]
HR expression
 ER+/PR+ 585 [65.6] 452 [65.8]
 ER+/PR− 104 [11.7] 78 [11.4]
 ER−/PR+ 14 [3.3] 15 [2.2]
 ER−/PR− 189 [21.2] 142 [20.7]
Intrinsic subtype
 Luminal A 219 [45] 108 [51.4]
 Luminal B 116 [23.9] 43 [20.5]
 HER2+/HR− 55 [11.3] 14 [6.7]
 Basal-like 88 [18.1] 40 [19]
 Normal-like 8 [1.7] 5 [2.4]
Combined TN status endpoint
 Luminal A 472 [74.8] 398 [76.7]
 Triple negative 159 [25.2] 121 [23.3]
  1. nH non-Hispanic, HR hormone receptor, ER/PR estrogen and progesterone receptor, HER2 human epidermal growth factor receptor-2
  2. To demonstrate the basic distribution of study covariates:
  3. aAn expression ‘flag’ marker (KCNK2) with no missing values is used (mRNA Expression z-scores, RNA Seq V2 RSEM)
  4. bA methylation ‘flag’ marker (cg21415530, KCNK9) with no missing values is used