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Table 1 Serum lipids in dams (gestation week 2) and newly weaned offspring (postnatal day 21) from mothers fed a chow diet, the chow diet supplemented with cholesterol (CH), or cholesterol and phytosterol (CH/PS) during gestation and lactation

From: Transcriptional control of enterohepatic lipid regulatory targets in response to early cholesterol and phytosterol exposure in apoE−/− mice

Endpoint

Chow

CH

CH/PS

Maternal lipids (mmol/L), gestation week 2

 Total-C

3.73 ± 0.51a

6.36 ± 1.23b

4.23 ± 0.34a

 Triglycerides

0.61 ± 0.02a

0.78 ± 0.09b

0.60 ± 0.02a

Offspring lipids (mmol/L), postnatal day 21

 Total-C

10.9 ± 0.4a

12.5 ± 0.5b

9.4 ± 0.3c

 LDL-C

2.6 ± 0.1a

3.62 ± 0.1b

1.88 ± 0.1c

 HDL-C

0.60 ± 0.0a

0.67 ± 0.1a

0.53 ± 0.0a

 Triglycerides

1.13 ± 0.0a

2.09 ± 0.4b

1.22 ± 0.1a

Offspring lipoprotein particle number (µmol/L), postnatal day 21

 Total LDL Particles

378.1 ± 27.7a

676.3 ± 114.0b

442.5 ± 28.5a

 Total HDL Particles

12.3 ± 0.5a

16.3 ± 1.6b

11.5 ± 0.5a

 Total VLDL Particles

217.9 ± 9.9a

292.4 ± 9.2b

201.3 ± 6.7a

  1. a, b, cGroups not sharing a superscript are significantly different (p < 0.05). Data are mean ± SE; n = 8 chow, n = 8 CH, n = 7 CH/PS