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Table 1 Serum lipids in dams (gestation week 2) and newly weaned offspring (postnatal day 21) from mothers fed a chow diet, the chow diet supplemented with cholesterol (CH), or cholesterol and phytosterol (CH/PS) during gestation and lactation

From: Transcriptional control of enterohepatic lipid regulatory targets in response to early cholesterol and phytosterol exposure in apoE−/− mice

Endpoint Chow CH CH/PS
Maternal lipids (mmol/L), gestation week 2
 Total-C 3.73 ± 0.51a 6.36 ± 1.23b 4.23 ± 0.34a
 Triglycerides 0.61 ± 0.02a 0.78 ± 0.09b 0.60 ± 0.02a
Offspring lipids (mmol/L), postnatal day 21
 Total-C 10.9 ± 0.4a 12.5 ± 0.5b 9.4 ± 0.3c
 LDL-C 2.6 ± 0.1a 3.62 ± 0.1b 1.88 ± 0.1c
 HDL-C 0.60 ± 0.0a 0.67 ± 0.1a 0.53 ± 0.0a
 Triglycerides 1.13 ± 0.0a 2.09 ± 0.4b 1.22 ± 0.1a
Offspring lipoprotein particle number (µmol/L), postnatal day 21
 Total LDL Particles 378.1 ± 27.7a 676.3 ± 114.0b 442.5 ± 28.5a
 Total HDL Particles 12.3 ± 0.5a 16.3 ± 1.6b 11.5 ± 0.5a
 Total VLDL Particles 217.9 ± 9.9a 292.4 ± 9.2b 201.3 ± 6.7a
  1. a, b, cGroups not sharing a superscript are significantly different (p < 0.05). Data are mean ± SE; n = 8 chow, n = 8 CH, n = 7 CH/PS