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Fig. 2 | BMC Research Notes

Fig. 2

From: Tissue-specific role of RHBDF2 in cutaneous wound healing and hyperproliferative skin disease

Fig. 2

The Rhbdf2 cub/cub mutation accelerates wound healing in MRL/MpJ “healer mice”. a The Rhbdf2 cub/cub mutation leads to complete hair loss in the MRL/MpJ strain. b Representative images of regenerating ear tissue in 8-week-old female MRL/MpJ and MRL/MpJ-Rhbdf2 cub/cub mice at 14 days post-wounding; (magnification = 4 ×; scale bars = 1 mm). c Quantification determined by measuring the area of the ear-holes shown in b; MRL/MpJ (n = 7), MRL/MpJ-Rhbdf2 cub/cub mice (n = 5). d H&E-stained cross-sections of ears from MRL/MpJ and MRL/MpJ-Rhbdf2 cub/cub mice at 0 and 14 days post-wounding. The dashed line indicates excision site; magnification = ×10, scale bars = 100 μm; (D) degree of proliferation. e, f ELISA quantitation of AREG levels in the supernatants of cultured MEFs and MEKs isolated from MRL/MpJ and MRL/MpJ-Rhbdf2 cub/cub mice, in response to stimulation with 100 nM PMA

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