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Table 1 Somatic and tumor MSI

From: An Msh3 ATPase domain mutation has no effect on MMR function

Marker Msh2-Msh3 +/+ Msh2-Msh3 GD/GD Msh2-Msh3 −/−
Somatic MSI
 U12335(A)n (5/95) 5% (16/72) 22% (1/99) 1%
 TG27 (3/90) 3% (8/95) 8% (11/75) 15%
 D7Mit91 (0/77) 0% (1/77) 1% (7/79) 9%
Tumor MSI
 U12335 (0/6) 0% (4/8) 50% (2/15) 13%
 TG27 (0/6) 0% (1/8) 13% (4/8) 50%
  1. Somatic and tumor microsatellite instability: MSI was analyzed using the mononucleotide marker U12235n and dinucleotide markers TG27 and D7Mit91 using pooled tail DNA from five each, Msh2-Msh3 +/+ , Msh2-Msh3 / and Msh2-Msh3 GD/GD mice, (p values U12335: Msh3+/+ vs. Msh3GD/GD = 0.036 and Msh3+/+: Msh3−/− = 0.02, p values TG27: Msh3+/+ vs. Msh3GD/GD = 0.06 and Msh3+/+ vs. Msh3−/− = 0.038, p values D7Mit91: Msh3+/+ vs. Msh3−/− = 0.05)