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Table 1 Diagnostic performance of the upregulated miRNA-based score

From: Urine cell-free microRNA as biomarkers for transitional cell carcinoma

Score cut-off Sensitivity Specificity Assumed prevalence 5% Assumed prevalence 20%
PPV NPV PPV NPV
1.140a 0.933 0.762 0.171 0.995 0.495 0.979
1.387 0.867 0.810 0.193 0.991 0.532 0.960
2.666 0.800 0.857 0.228 0.988 0.583 0.945
  1. PPV positive predictive value, NPV negative predictive value
  2. a1.140 is the optimal cut-off point according to Youden’s criterion