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Table 1 Diagnostic performance of the upregulated miRNA-based score

From: Urine cell-free microRNA as biomarkers for transitional cell carcinoma

Score cut-off

Sensitivity

Specificity

Assumed prevalence 5%

Assumed prevalence 20%

PPV

NPV

PPV

NPV

1.140a

0.933

0.762

0.171

0.995

0.495

0.979

1.387

0.867

0.810

0.193

0.991

0.532

0.960

2.666

0.800

0.857

0.228

0.988

0.583

0.945

  1. PPV positive predictive value, NPV negative predictive value
  2. a1.140 is the optimal cut-off point according to Youden’s criterion