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Table 2 Effect of chronic oral administration of G. stenophylla root extract on some hematological parameters in mice

From: Toxicological investigation of acute and chronic treatment with Gnidia stenophylla Gilg root extract on some blood parameters and histopathology of spleen, liver and kidney in mice

Hematological parameters

Control (DW)

Treatment groups (mg/kg body weight/day)

400

800

RBC (× 106/µL)

3.44 ± 0.65

3.92 ± 0.66 (0.616)

6.04 ± 0.64 (0.040)*

HGB (g/dL)

5.35 ± 0.92

6.40 ± 1.11 (0.501)

9.48 ± 1.06 (0.042)*

HCT (%)

16.87 ± 3.28

19.23 ± 3.42 (0.627)

29.43 ± 3.05 (0.048)*

MCV (fL)

48.73 ± 1.44

48.77 ± 0.80 (0.976)

48.73 ± 0.12 (0.996)

MCH (pg)

15.70 ± 0.51

16.32 ± 0.28 (0.229)

115.70 ± 0.10 (1.00)

MCHC (g/dL)

32.20 ± 0.89

33.48 ± 0.37 (0.124)

32.20 ± 0.26 (1.00)

RDW (%)

17.98 ± 1.26

17.58 ± 0.74 (0.776)

20.17 ± 1.15 (0.198)

PLT (× 103/µL)

215.25 ± 44.88

266.67 ± 49.12 (0.456)

315.33 ± 38.32 (0.231)

WBC (× 103/µL)

6.02 ± 0.79

5.97 ± 0.79 (0.975)

4.89 ± 1.74 (0.483)

Neutrophils (%)

0.24 ± 0.09

0.44 ± 0.19 (0.565)

0.67 ± 0.48 (0.292)

Lymphocytes (%)

87.13 ± 5.58

92.20 ± 1.58 (0.507)

65.60 ± 11.94 (0.033)*

Monocytes (%)

2.73 ± 1.57

2.01 ± 0.91 (0.706)

2.16 ± 2.15 (0.796)

Eosinophils (%)

1.61 ± 0.65

1.25 ± 0.46 (0.646)

1.17 ± 0.63 (0.635)

Basophils (%)

7.79 ± 3.58

4.11 ± 0.57 (0.641)

30.40 ± 14.37 (0.031)*

  1. Values are given as mean ± S.E.M. n = 10. The figures under brackets indicate the calculated P values of the treatment groups as compared to the control
  2. *The mean difference is statistically significant at P value < 0.05