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Table 2 Mutations associated with INH and RIF drug resistant M. tuberculosis clinical isolates

From: Performance of MTBDRplus assay in detecting multidrug resistant tuberculosis at hospital level

Phenotypic DST RIF susceptibility pattern Phenotypic DST INH susceptibility pattern
RpoB gene KatG gene InhA gene
WT 1/8 Mutant WT Mutant WT1 WT2 Mutant Frequency
R 530–533 (WT8) S531L R 315 S315T1 35
R 510–513 (WT2) S531L R 315 S315T1 1
R 516–519 (WT4) S531L R 315 S315T1 2
R 513–517 (WT3)
516–519 (WT4)
D516V R 315 S315T1 2
R 513–517 (WT3)
516–519 (WT4)
R 315 S315T1 1
R 513–517 (WT3)
516–519 (WT4)
530–533 (WT8)
S531L R 315 S315T1 1
R 526–529 (WT7) R 315 S315T1 2
R 526–529 (WT7) H526Y R 315 S315T1 2
R 526–529 (WT7) S531L R 315 S315T1 1
R 526–529 (WT7) H526Y R 315 S315T1 1
R H526Y Ra 1
S R 315 S315T1 4
S Ra 1
  1. aMTBDRplus INH susceptible and INH resistant by phenotypic DST