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Table 2 Time intervals and potential determinants

From: Clinical interval and diagnostic characteristics in a cohort of bladder cancer patients in Spain: a multicenter observational study

Hospital random effect empty model Time interval between first consultation and first diagnosis Time interval between diagnosis and first treatment
   Empty model ICC/MOR 0.05/1.47 95% CI MOR 1.14–3.06 P-value 0.037    Empty model ICC/MOR 0.26/2.81 95% CI MOR 1.56–11.06 P-value < 0.001
Median (days) IQR (days) OR > 100 days 95% CI OR P-value Median (days) IQR (days) OR > 30 days 95% CI OR P-value
Univariate regression
 Gender
  Male 104 113 1    0 366 1   
  Female 108.5 104 1.11 (0.58–2.10) 0.760 0 60 1.31 (0.44–3.87) 0.630
 Age
  < 65 104 105 1    0 203 1   
  ≥ 65 107.5 114 0.99 (0.61–1.62) 0.976 0 366 0.99 (0.40–2.46) 0.984
 BMI
  < 25 90 99 1    0 364 1   
  ≥ 25 110 116 1.39 (0.83–2.32) 0.211 0 366 0.39 (0.16–0.94) 0.037
 Education level
  Primary education or lower 102.5 107 1    0 366 1   
  Graduate school or higher 110 119 1.39 (0.86–2.24) 0.174 0 364 1.18 (0.49–2.85) 0.714
 ECOG WHO score
  Fully active 103.5 115 1    0 364 1   
  Restricted or worse 111 110 1.29 (0.80–2.06) 0.295 0 366 0.78 (0.32–1.91) 0.586
 Specialist first consultation*
  Primary care 115 116 1    0 364 1   
  Hospital or specialist 91.5 104 0.61 (0.38–0.97) 0.038 0 366 0.99 (0.41–2.41) 0.981
 Primary tumour clinical stage^
  T1 110 109.5 1    0 366 1   
  T2a–T4 102 120 0.78 (0.44–1.40) 0.404 0 364 4.39 (1.72–11.21) 0.002
 Time since first symptom
  Up to 1 month 56.5 103 1    0 366 1   
  More than 1 month 110.5 110 2.38 (1.25–4.51) 0.008 0 364 1.03 (0.32–3.34) 0.959
  Final model ICC/MOR 95% CI MOR P-value Final model ICC/MOR 95% CI MOR P-value     
Multivariate regression     
 Hospital random effect 0.05/1.48 1.12–3.78 0.078 0.29/3.06 1.63–13.1 < 0.001     
  1. BMI body mass index, IQR interquartile range, SD standard deviation, OR odds ratio, ICC intra-cluster correlation coefficient, MOR median odds ratio
  2. *  In the multivariate analysis to consult first Hospital or specialist shortened the time to diagnosis compared to consult Primary Care, OR 0.61 [0.38–0.97]
  3. ^In the multivariate analysis the clinical stage T2a–T4 lengthened the time to treatment compared with clinical stage T1, OR 4.39 [1.72–11.21]