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Table 1 Clinical Follow-up of Tg concentrations detected by RIA but undetected/low by EIA or LC MS/MS

From: Clinical laboratory verification of thyroglobulin concentrations in the presence of autoantibodies to thyroglobulin: comparison of EIA, radioimmunoassay and LC MS/MS measurements in an Urban Hospital

Sample# EIA
(ng/mL)
RIA
(ng/mL)
LC MS/MS
(ng/mL)
Thyroid cancer Subsequent progression Subsequent Tg measurements Months monitored Imaging
26 0 2.8 < 0.4 PTC No detectable disease No change 24 Negative
27 0 4.1 < 0.4 PTC (metastatic) No progression since 2007 No change 24 Negative—neck only
28 0 2.1 < 0.4 PTC No detectable disease No change 18 Negative
29 0 2.4 < 0.4 PTC No detectable disease No change 14 Negative
30 0 2.3 < 0.4 PTC (metastatic) No detectable disease No change 13 Negative
31 0 3 < 0.4 PTC No detectable disease No change 17 Negative
32 0 3.2 < 0.4 PTC Recurrence No change 11 No progression
33 0 2 < 0.4 PTC No detectable disease No change 18 Negative
34 0.39 3.8 0.8 PTC No detectable disease No change 18 Remnant
50 1.68 15 3.28 Graves disease No follow-up for disease NA NA NA