Risk factors for bone loss in patients with rheumatoid arthritis treated with biologic disease-modifying anti-rheumatic drugs

Table 3 Multivariate analysis for LSR reduction of lumber spine and femoral neck BMD

Nagelkerke R²: 0.10	Lumber spine
Nagelkerke R²: 0.10	Odds ratio	p value
Average dose of prednisolone	1.22 (1.02–1.50)	0.03
Type of anti-osteoporosis drugs	1.52 (0.87–2.65)	0.14
CRP	1.46 (0.95–2.25)	0.08

Nagelkerke R²: 0.08	Femoral neck
Nagelkerke R²: 0.08	Odds ratio	p value
Sex	2.37 (0.82–6.90)	0.11
Disease duration	0.95 (0.91–0.10)	0.04
Average dose of prednisolone	1.13 (0.97–1.32)	0.11

The stepwise binomial logistic regression detected high dose of prednisolone use is a risk factors for 12-month LSR of lumbar spine (≤ − 2.4%). The stepwise binomial logistic regression analysis detected short disease duration is a risk factors for 12-month LSR of femoral neck (≤ − 1.9%)
LSR least significant reduction, BMD bone mineral density, CRP serum C-reactive protein concentration

ISSN: 1756-0500