Fig. 1

a Raw CT values of microRNA measurements in plasma and exosomes. b Levels of miR-486 and miR-146a in plasma and exosomes of patients experiencing heart failure (n = 40) compared to healthy controls (n = 20). Fold changes indicate ratio between indicated test microRNA versus abundantly and ubiquitously expressed/released miR-16. c The effects of Tnfα and Gm-csf on miR-146a and miR-486 expression in H9C2 cardiomyocytes. Cells maintained in DMEM plus 10% FBS were treated with Tnfα and Gm-csf at a concentration of 10 ng/ml for 24 h and microRNA levels were measured. miR-146a/miR-16 (n = 4, *p < 0.05, control vs. cytokine treatment) and miR-486/miR-16 ratio is presented