Table 1 Patients’ clinical data vs polymorphisms distribution
Parameter | CYP2C19*2 | P value | CYP2C19*3 | P value | CYP2C19*17 | P value | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
GG % | GA % | AA % | GG % | GA % | AA % | CC % | CT % | TT % | ||||
Familial antecedents | 0.8 | 0.1 | 0.3 | |||||||||
(+) | 0 | 100 | 0 | 0 | 0 | 100 | 50 | 50 | 0 | |||
(−) | 7.1 | 82.1 | 10.8 | 3.9 | 76.5 | 19.6 | 15.4 | 63.1 | 21.5 | |||
Personal antecedents | 0.1 | NC | 0.002** | |||||||||
(+) | 16.7 | 72.2 | 11.1 | 4.5 | 68.2 | 27.3 | 3.6 | 57.1 | 39.3 | |||
(−) | 2.5 | 87.5 | 10 | 0 | 0 | 0 | 26.3 | 65.8 | 7.9 | |||
Blood pressure | 0.3 | 0.9 | 0.3 | |||||||||
(+) | 13 | 78.3 | 8.7 | 4 | 76 | 40 | 16.7 | 61.1 | 22.2 | |||
(−) | 2.9 | 85.7 | 11.4 | 5.7 | 77.1 | 17.2 | 20.8 | 70.8 | 8.3 | |||
Smoking | 0.8 | 0.2 | 0.8 | |||||||||
(+) | 8.7 | 82.6 | 8.7 | 8.7 | 82.6 | 8.7 | 16.1 | 64.5 | 19.4 | |||
(−) | 5.7 | 82.9 | 11.4 | 2.7 | 73 | 24.3 | 12.9 | 61.3 | 25.8 | |||
Diabetes | 0.1 | 0.4 | 0.1 | |||||||||
(+) | 14.3 | 71.4 | 14.3 | 8 | 80 | 12 | 16.1 | 58.1 | 25.8 | |||
(−) | 2.7 | 89.2 | 8.1 | 2.9 | 74.3 | 22.8 | 11.5 | 80.8 | 7.7 | |||
Dyslipidemia | 0.5 | 0.5 | 0.1 | |||||||||
(+) | 25 | 75 | 0 | 11.1 | 66.7 | 22.2 | 14.2 | 42.9 | 42.9 | |||
(−) | 11.1 | 77.8 | 11.1 | 0 | 77.8 | 22.2 | 10 | 80 | 10 | |||