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Table 3 Association of clinicopathological and prognostic parameters of colorectal carcinoma with N stage

From: Clinicopathologic features of colorectal carcinoma: features predicting higher T-stage and nodal metastasis

Variable N stage P value
N0 N1 N2a N2b
Age (years)
 < 50 10 8 9 10 0.19
 > 50 22 22 10 9  
Gender
 Male 18 13 10 10 0.777
 Female 14 17 9 9  
Laterality
 Right 6 11 5 8 0.26
 Left 26 19 14 11  
Lymphovascular invasion
 Present 0 8 9 10 < 0.001*
 Absent 32 22 10 9  
Grade
 Well differentiated 3 0 0 0 < 0.001*
 Moderately differentiated 27 26 16 7  
 Poorly differentiated 2 4 3 12  
Tumor type
 Adenocarcinoma, NOS 29 27 16 8 0.006*
 Mucinous carcinoma 2 2 2 7  
 Medullary carcinoma 1 0 0 1  
 Signet ring cell carcinoma 0 1 1 3  
Perinodal spread
 Present 0 13 15 19 < 0.001*
 Absent 32 17 4 0  
Mucinous histology (%)
 Absent 26 20 15 7 0.006*
 < 10 2 6 2 2  
 10–50 3 0 0 4  
 > 50 1 4 2 6  
Signet ring differentiation
 Present 1 5 2 8 0.003*
 Absent 31 25 17 11  
Medullary differentiation
 Present 1 0 0 0 0.543
 Absent 31 30 19 19  
Necrosis
 Absent 1 2 3 0 0.097
 Focal 22 20 10 18  
 Widespread 9 8 6 1  
Tumor infiltrating lymphocytes
 None 14 15 13 16 0.019*
 Mild-moderate 7 9 5 3  
 Marked 11 6 1 0  
Peri-tumoral lymphocytes
 None 21 24 12 10 0.639
 Mild-moderate 6 3 4 5  
 Marked 5 3 3 4  
Pre-existing polyp
 Present 7 2 1 0 0.047*
 Absent 25 28 18 19  
  1. Chi square test applied
  2. * P-value is significant
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