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Table 1 Evaluation of different quality control parameter of esomeprazole [10, 18, 20, 21]

From: In vitro comparative quality evaluation of different brands of esomeprazole tablets available in selected community pharmacies in Dhaka, Bangladesh

Sample

Weight variation (%)a

Hardness (Kgf)b

Disintegration (Min)c

Potency (%)d

(Mean ± % RSD)

E01

1.20 ± 0.23

5.32 ± 0.06

29.05 ± 0.14

95.28 ± 0.08

E02

1.41 ± 0.54

6.71 ± 0.02

26.83 ± 0.09

98.45 ± 0.16

E03

2.01 ± 0.14

5.76 ± 0.14

19.93 ± 0.04

99.40 ± 0.11

E04

1.01 ± 0.29

6.26 ± 0.09

26.28 ± 0.18

98.63 ± 0.13

E05

1.21 ± 0.42

7.12 ± 0.12

28.18 ± 0.02

98.87 ± 0.06

USP specification

NMT ± 5% to ± 7.5%

4–8 kgf

5–30 min

95–105%

  1. a20 time replication for each brand
  2. b10 time replication for each brand
  3. c6 time replication for each brand
  4. d3 time replication for each brand