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Table 2 Association of CK 5/6 expression with clinicopathologic features of bladder cancer

From: Cytokeratin 5/6 expression in bladder cancer: association with clinicopathologic parameters and prognosis

  CK 5/6 n (%) P value
Positive Negative Focal positive Total
Gender
 Male 8 (100) 77 (75.5) 8 (47.1) 93 (73.2) 0.014
 Female 0 (0) 25 (24.5) 9 (52.9) 34 (26.8)
 Total 8 102 17 127  
Age group
 ≤ 25 years 0 (0) 1 (1) 0 (0) 1 (0.8) 0.613
 26–50 years 2 (25) 26 (25.5) 2 (11.8) 30 (23.6)
 > 50 years 6 (75) 75 (73.5) 15 (88.2) 96 (75.6)
 Total 8 102 17 127  
Tissue type
 Transurethral resection 6 (75) 99 (97.1) 17 (100) 122 (96.1) 0.049
 Radical cystectomy 2 (25) 3 (2.9) 0 (0) 5 (3.9)
 Total 8 102 17 127  
Tumor grade
 Low grade 0 (0) 59 (57.8) 5 (29.4) 64 (50.4) 0.000
 High grade 8 (100) 43 (42.2) 12 (70.6) 63 (49.6)
Total 8 102 17 127  
Lamina propria invasion
 Present 5 (62.5) 31 (30.4) 3 (17.6) 39 (30.7) 0.081
 Absent 3 (37.5) 71 (69.6) 14 (82.4) 88 (69.3)
 Total 8 102 17 127  
Deep muscle invasion
 Present 5 (62.5) 19 (18.6) 2 (11.8) 26 (20.5) 0.049
 Absent 1 (12.5) 47 (46.1) 10 (58.8) 58 (45.7)
 Can’t assessed 2 (25) 36 (35.3) 5 (29.4) 43 (33.9)
 Total 8 102 17 127  
Recurrence (n = 54)
 Yes 2 (50) 18 (40) 2 (40) 22 (40.7) 1.000
 No 2 (50) 27 (60) 3 (60) 32 (59.3)
 Total 4 45 5 54  
Survival status (n = 54)
 Alive 3 (75) 39 (86.7) 5 (100) 47 (87) 0.514
 Expired 1 (25) 6 (13.3) 0 (0) 7 (13)
 Total 4 45 5 54  
  1. Fisher exact test applied
  2. P ≤ 0.05, considered as significant