Table 1 CD6 genotype and diet effects in male mice
From: CD6 expression has no effect on atherosclerosis in apolipoprotein E-deficient mice
Phenotype | Chow diet | Western type diet | Diet effect | Genotype | Interaction | ||||
|---|---|---|---|---|---|---|---|---|---|
K0 | DK0 | T-test | K0 | DK0 | T-test | P value | P value | P value | |
Male mice | |||||||||
 Body weight (g) | 28.3 ± 3.2 (14) | 28 ± 1.5 (6) | N.S | 35.5 ± 4.0 (8) | 31.8 ± 3.4 (6) | N.S | < 0.0001 | N.S | N.S |
 Cholesterol (mg/dl) | 1251 ± 161.1 (10) | 1179 ± 143.1 (5) | N.S | 2518 ± 257.5 (8) | 2876 ± 507.7 (6) | N.S | < 0.0001 | N.S | N.S |
 HDL-C (mg/dl) | 86 ± 26.3 (8) | 79 ± 28.2 (5) | N.S | 146 ± 88.4 (8) | 130.2 ± 63.7 (6) | N.S | 0.026 | N.S | N.S |
 IgM (μg/ml) | 55.6 ± 33.5 (14) | 54.3 ± 27.1 (6) | N.S | 70.2 ± 29.8 (8) | 102.3 ± 16.3 (6) | 0.036 | 0.006 | N.S | N.S |
 Pc-IgM (OD read) | 0.15 ± 0.1 (14) | 0.21 ± 0.11 (5) | N.S | 0.51 ± 0.22 (8) | 0.7 ± 0.21 (6) | N.S | < 0.0001 | 0.042 | N.S |
 B1a cells (% of total cells) | 4.17 ± 1.43 (10) | 3.96 ± 0.8 (5) | N.S | 1.8 ± 1.22 (5) | 2.93 ± 1.36 (6) | N.S | 0.0026 | N.S | N.S |
 Lesion area (μm2) | 114,960 ± 52,300 (14) | 95,595 ± 43,576 (6) | N.S | 507,311 ± 209,049 (8) | 674,382 ± 292,443 (6) | N.S | < 0.0001 | N.S | N.S |