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Table 2 Distribution of risk factors and complications, clinical characteristics of SHCLCI according to vaccination status, PIDIRAC 2010–2015

From: Descriptive study of severe hospitalized cases of laboratory-confirmed influenza during five epidemic seasons (2010–2015)

Risk factor (%) Complications (%)  
Heart disease 25.5 Pneumonia 71.5  
Asthma 6.5 Bacterial coinfection 30.5  
COPD 22.6 ARDS   
Diabetes 20.5 (Acute respiratory distress syndrome) 37.7  
Immunodeficiency 17.5 Multi organic failure 10.5  
Others (including cancers) 7    
Chronic renal disease 11    
Obesity (BMI ≥ 40) 8    
Chronic liver disease 5.5    
Pregnancy 1.6    
Smokinga 37.6    
Clinical characteristic
Total cases (%)
Vaccinatedb
N/cases (%)
285 (29.5%)
Unvaccinatedb
N/cases (%)
682 (70.5%)
OR (95% CI) p
Complication pneumonia
998 cases (71.7)
198/284 505/678 0.79 (95% CI 0.58–1.07) 0.07
Bacterial superinfection
309 cases (30.6)
61/188 155/470 0.97 (95% CI 0.68–1.40) 0.58
ARDS
518 cases (37.7)
101/284 205/676 1.20 (95% CI 0.94–1.7) 0.06
Multi organ failure
813 cases (10.1)
31/282 57/671 1.20 (95% CI 0.94–1.7) 0.13
ICU admission
462 cases (33)
71/285 232/682 0.64 (95% CI 0.47–0.88) 0.003
  1. aMissing data in 91% of cases
  2. bCases with information. Missing information on immunization status in 433 cases (31%)