From: Concurrent interactome and metabolome analysis reveals role of AKT1 in central carbon metabolism
Metabolite | Control (percentage incorporation/unit time) | MK-2206 treated (percentage incorporation/unit time) | Ratio (MK+/MK−) | |||||||
---|---|---|---|---|---|---|---|---|---|---|
13C | 12C | Inflow | Outflow | 13C | 12C | Inflow | Outflow | Inflow | Outflow | |
G6P | 13.333 | 14.286 | 27.619 | 14.286 | 14.286 | 15.385 | 29.670 | 15.385 | 1.074 | 1.077 |
FBP | 14.286 | 15.789 | 30.075 | 15.789 | 10.526 | 9.615 | 20.142 | 9.615 | 0.670 | 0.609 |
DHAP | 15.000 | 15.385 | 30.385 | 15.385 | 12.000 | 12.500 | 24.500 | 12.500 | 0.806 | 0.813 |
3PG/2PG | 16.000 | 16.667 | 32.667 | 16.667 | 12.500 | 13.043 | 25.543 | 13.043 | 0.782 | 0.783 |
PEP | 18.182 | 18.182 | 36.364 | 18.182 | 15.385 | 15.385 | 30.769 | 15.385 | 0.846 | 0.846 |
Pyruvate | 16.364 | 15.385 | 31.748 | 15.385 | 12.000 | 12.500 | 24.500 | 12.500 | 0.772 | 0.813 |
AcoA | 2.885 | 2.667 | 5.551 | 2.667 | 1.288 | 1.133 | 2.421 | 1.133 | 0.436 | 0.425 |
Citrate | 2.793 | 5.000 | 7.793 | 5.000 | 1.213 | 4.000 | 5.213 | 4.000 | 0.669 | 0.800 |
OXA | 0.997 | 0.900 | 1.897 | 0.900 | 0.821 | 0.800 | 1.621 | 0.800 | 0.854 | 0.889 |
R5P | 6.225 | 6.667 | 12.891 | 6.667 | 4.452 | 6.250 | 10.702 | 6.250 | 0.830 | 0.938 |
IMP | 0.315 | 0.417 | 0.732 | 0.417 | 0.180 | 0.200 | 0.380 | 0.200 | 0.520 | 0.480 |
AKG | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 1.000 | 1.000 |
Succinate | 0.372 | 0.400 | 0.772 | 0.400 | 0.302 | 0.333 | 0.635 | 0.333 | 0.823 | 0.833 |
Malate | 0.386 | 0.333 | 0.720 | 0.333 | 0.340 | 0.267 | 0.607 | 0.267 | 0.843 | 0.800 |