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Table 1 Inflow and outflow rates for the targeted metabolites in CCM pathways

From: Concurrent interactome and metabolome analysis reveals role of AKT1 in central carbon metabolism

Metabolite

Control (percentage incorporation/unit time)

MK-2206 treated (percentage incorporation/unit time)

Ratio (MK+/MK−)

13C

12C

Inflow

Outflow

13C

12C

Inflow

Outflow

Inflow

Outflow

G6P

13.333

14.286

27.619

14.286

14.286

15.385

29.670

15.385

1.074

1.077

FBP

14.286

15.789

30.075

15.789

10.526

9.615

20.142

9.615

0.670

0.609

DHAP

15.000

15.385

30.385

15.385

12.000

12.500

24.500

12.500

0.806

0.813

3PG/2PG

16.000

16.667

32.667

16.667

12.500

13.043

25.543

13.043

0.782

0.783

PEP

18.182

18.182

36.364

18.182

15.385

15.385

30.769

15.385

0.846

0.846

Pyruvate

16.364

15.385

31.748

15.385

12.000

12.500

24.500

12.500

0.772

0.813

AcoA

2.885

2.667

5.551

2.667

1.288

1.133

2.421

1.133

0.436

0.425

Citrate

2.793

5.000

7.793

5.000

1.213

4.000

5.213

4.000

0.669

0.800

OXA

0.997

0.900

1.897

0.900

0.821

0.800

1.621

0.800

0.854

0.889

R5P

6.225

6.667

12.891

6.667

4.452

6.250

10.702

6.250

0.830

0.938

IMP

0.315

0.417

0.732

0.417

0.180

0.200

0.380

0.200

0.520

0.480

AKG

0.000

0.000

0.000

0.000

0.000

0.000

0.000

0.000

1.000

1.000

Succinate

0.372

0.400

0.772

0.400

0.302

0.333

0.635

0.333

0.823

0.833

Malate

0.386

0.333

0.720

0.333

0.340

0.267

0.607

0.267

0.843

0.800

  1. G6P glucose-6-phosphate, FBP fructose-1,6 bis-phosphate, DHAP dihydroxy acetone phosphate, 3PG/2PG 3/2-phosphoglycerate, PEP phosphoenolpyruvate, AcoA acetyl-CoA, OXA oxaloacetate, R5P ribulose-5-phosphate, IMP inosine monophosphate, AKG alpha-ketoglutarate