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Table 2 Effect of MK2206 on the rate of fatty acid synthesis at 0 and 7 h

From: Concurrent interactome and metabolome analysis reveals role of AKT1 in central carbon metabolism

Metabolite

0 h

7 h

MK-2206(−) 13C (−)

MK-2206(−) 13C (+)

MK-2206(+) 13C (+)

Replicate1

Replicate2

Replicate1

Replicate2

Replicate1

Replicate2

12C (255)

4.73E+07

3.14E+07

1.22E+07

1.48E+07

5.16E+07

1.14E+08

13C (257)

3.10E+06

4.01E+06

8.86E+06

1.07E+07

4.80E+06

9.95E+06

13C (265)

4.45E+06

5.47E+06

7.93E+06

1.39E+07

1.34E+07

1.11E+07

13C (271)

1.31E+06

1.22E+06

4.62E+06

3.96E+06

3.49E+06

5.20E+06

% 13C incorporation

15.776

25.416

63.701

65.867

29.595

18.716

%13C (average)

20.596

64.784

24.156

  1. The experiment was conducted in duplicates for each condition and four separate peaks were tracked depicting 12C and 13C incorporation respectively