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Fig. 3 | BMC Research Notes

Fig. 3

From: Modelling steroidogenesis: a framework model to support hypothesis generation and testing across endocrine studies

Fig. 3

Using the model to predict the outcome of a HSD17B knockout in Leydig cells. a The labelling of the HSD17B protein activity node in a wild-type model. b The removal of the arrow between the token input and the protein node sets token input to zero and models a knockout of the protein. c A still frame from the dynamic signalling Petri net outputs of the HSD17B knockout Leydig cell model at the adult stage. Each of the coloured shapes on the diagram represents a steroid node in the same position as the yED diagram above. Larger red shapes indicate more tokens are flowing through that node, smaller blue shapes indicate fewer and no shape indicates no tokens. d A graph visualising the flow of tokens through the nodes representing testosterone (blue) and androstenediol (green) over the course of Leydig cell maturation. The coloured areas around the line indicate the variance of the output

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