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Table 1 Effect of HIV-1 Tat peptide on resting membrane potential (RMP), input resistance (Rin), action potential threshold, and rheobase in hippocampal pyramidal neurons

From: HIV-1 Tat alters neuronal intrinsic excitability

 

RMP (mV)

Rin (MW)

Threshold (mV)

Rheobase (nA)

Gain (Spike/S)

Control

68.52 ± 0.33

53.06 ± 0.889

43.36 ± 0.201

0.33 ± 0.071

1.9 ± 0.7

HIV-1 Tat 24 h

68.56 ± 0.63

53.04 ± 1.12

43.7 ± 0.466

0.31 ± 0.032

5.9 ± 0.6

t test

0.956

0.989

0.522

0.543

1.678E−10**

  1. The Tat peptide was added to the cultures, and electrophysiological parameters were tested at 24 h