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Table 2 Phenotype-associated single nucleotide polymorphisms (SNPs) and predicted impact of minor allele on binding sites for transcription factors within the human ICAM-1-related (ICR) gene promoter

From: ICAM-1-related long non-coding RNA: promoter analysis and expression in human retinal endothelial cells

SNP

Alleles

Minor allele

Transcription factors with binding sites in ICR promoter

Impact of minor allele on binding sites

Frequency

Associations

Loss

Gain

rs2569693

C/T

0.31

Systemic lupus erythematosus [1]

sICAM-1 level [18]

ELF1, POL2, NFKB, MAX, CMYC, E2F6, MXI1, FOXA1, CHD2, HMGN3, ZNF263

PLAGL1, WT1, EGR2, ZKSCAN3, ZBED4, INSM1, MAZR, SALL2,

SPZ1

MOK2

rs281439

C/G

0.32

Breast cancer [19]

USF1, USF2, USF3, FOXA1, SIN3AK20, POL2, NFKB, MAX, CMYC, E2F6, MXI1, POL24H8, TCF12, BHLHEAD, HMGN3, IRF1, TBP, YY1, ZNF263

USF

E2F6, GCM1, XCPE

rs281440

A/G

0.30

sICAM-1 level [20]

POL2, TBP, EGR1, SRF, IRF, POL24H8, GATA2, ZNF263

KKLF, ZBTB7, LRRFIP1, E2F4

NM23, MAZR

none

rs2075741

G/C

0.33

Breast cancer [19]

Prostate cancer [19]

sICAM-1 level [20]

POL2, TAF1, ZNF263

None

DMTE

rs11575074

G/A

0.07

sICAM-1 level [21]

POL2, TAF1, SUZ12, ZNF263

NF1B

MYBL1, MEIS1A_ HOXA9, PTF1

  1. sICAM-1 soluble intercellular adhesion molecule 1