Skip to main content

Table 1 Common medications that can interact with sulfonylureas [1, 2, 5, 6]

From: Unintentional sulfonylurea toxicity due to a drug–drug interaction: a case report

Drug Mechanism Effect
Fluconazole, ketoconazole, voriconazole, amiodarone, co-trimoxazole (sulfamethoxazole component), fluoxetine, fluvoxamine, metronidazole Inhibition of CYP2C9 Hypoglycemia
Carbamazepine, phenobarbital, rifampin, St. John’s wort, dexamethasone Induction of CYP2C9 Reduced efficacy (hyperglycemia)