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Table 1 Patient’s blood test results, virology results including serology (A) and PCR results from vesicle fluid (B), confirming primary VZV infection, and histology summary from splenic tissue (C)

From: Spontaneous splenic rupture complicating primary varicella zoster infection: a case report

A) Blood results:

Haemoglobin

110 g/l

CRP

59 mg/l

Malaria parasites

None seen

MCV

91.3 fl

Bilirubin

26 μmol/l

EBV VCA IgG

Negative

Platelets

78 × 109/l

Alkaline phosphatase

27 IU/l

EBV VCA IgM

Negative

White cell count

3.6 × 109/l

Alanine aminotransferase

27 IU/l

EBV EBNA IgG

Positive

Neutrophils

2.4 × 109/l

Albumin

35 g/l

CMV IgG

Positive

Lymphocytes

0.6 × 109/l

Sodium

134 mmol/l

CMV IgM

Negative

Eosinophils

0.0 × 109/l

Potassium

4.4 mmol/l

HIV-1 and 2

Non reactive

Blood film

Thrombocytopenia. Stomatocytes seen

Urea

7.8 mmol/l

Hep B surface antigen

Non reactive

INR

1.0

Creatinine

70 μmol/l

Hep B core antibody

Negative

Prothrombin time

11.4 s

Amylase

33 IU/l

Hep C antibody

Negative

APTT

33.0 s

Lactate

1.2

Urine Chlamydia DNA

Negative

APTT ratio

1.10

Bicarbonate

24

VZV IgG

Equivocal

B) Vesicle fluid investigations

VZV DNA

Detected

HSV DNA

Not detected

C) Histology report summary

Spleen shows normal histology with subcapsular haematoma and a minor degree of intraparenchymal haemorrhage. The splenic white pulp and red pulp appear normal. No granulomas are seen, there is no evidence of a neoplastic process. In situ hybridisation for EBV is negative and Congo red stains for amyloid deposition is also negative