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Table 3 Comparison of clinical features of our GPA patients with other experiences

From: Granulomatosis with polyangiitis: a 17 year experience from a tertiary care hospital in Pakistan

 

Mahr et al. 2013, Europe

Holle et al.[9], Germany

Reinold-Keller et al. [6], Germany

Stone et al. (2002), USA

Shobha et al. (2018), India

Kumar et al. (2015), India

Sharma et al. [24], India

Our study, 2018

Total no. of patients

396

445

155

180

60

45

105

51

Male/female %

54/46

50/50

49/51

60/40

35/25

42/58

43/57

55/45

Mean age at diagnosis

55

51

48

47

44

46

40

44

Study period

1995–2003

1996–2002

1966–1993

2000–2003

2002–2010

2009–2014

2005–2016

2000–2017

Mean duration of follow up, years

4.75

6

7

NA

4.7

NA

3.1

NA

c-ANCA/PR-3 positivity (%)

–/79

81/80

84

76/73

93

62/38

82/62

51/100

p-ANCA/MPO positivity (%)

–/11

4

3/–

11/12

7

11/7

9/7

11/21

Organ involvement (%)

 ENT

84

98

93

90

21

80

79

49

 Joints

NA

73

61

81

27

42

44

43

 Lung

67

60

55

75

63

49

68

80

 Kidney

77

60

54

68

70

33

31

55

 Eye

39

40

40

41

11

31

41

12

 Nervous system

14

17

11

10

25

10

19

18

 Skin

30

26

21

39

48

9

30

16

 Heart

10

11

13

4

1

7

6

NA

 GIT

7

3

3

7

NA

9

12

NA

 Relapses,%

47

50

64

NA

13

53

31

18

 Expired,%

14

10

14

NA

18

NA

17

18

  1. c-ANCA, cytoplasmic antineutrophil cytoplasmic antibody; ENT, ear nose and throat; GIT, gastrointestinal tract; MPO, myeloperoxidase; p-ANCA, perinuclear antineutrophil cytoplasmic antibody; PR3, proteinase 3