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Table 3 Comparison of clinical features of our GPA patients with other experiences

From: Granulomatosis with polyangiitis: a 17 year experience from a tertiary care hospital in Pakistan

  Mahr et al. 2013, Europe Holle et al.[9], Germany Reinold-Keller et al. [6], Germany Stone et al. (2002), USA Shobha et al. (2018), India Kumar et al. (2015), India Sharma et al. [24], India Our study, 2018
Total no. of patients 396 445 155 180 60 45 105 51
Male/female % 54/46 50/50 49/51 60/40 35/25 42/58 43/57 55/45
Mean age at diagnosis 55 51 48 47 44 46 40 44
Study period 1995–2003 1996–2002 1966–1993 2000–2003 2002–2010 2009–2014 2005–2016 2000–2017
Mean duration of follow up, years 4.75 6 7 NA 4.7 NA 3.1 NA
c-ANCA/PR-3 positivity (%) –/79 81/80 84 76/73 93 62/38 82/62 51/100
p-ANCA/MPO positivity (%) –/11 4 3/– 11/12 7 11/7 9/7 11/21
Organ involvement (%)
 ENT 84 98 93 90 21 80 79 49
 Joints NA 73 61 81 27 42 44 43
 Lung 67 60 55 75 63 49 68 80
 Kidney 77 60 54 68 70 33 31 55
 Eye 39 40 40 41 11 31 41 12
 Nervous system 14 17 11 10 25 10 19 18
 Skin 30 26 21 39 48 9 30 16
 Heart 10 11 13 4 1 7 6 NA
 GIT 7 3 3 7 NA 9 12 NA
 Relapses,% 47 50 64 NA 13 53 31 18
 Expired,% 14 10 14 NA 18 NA 17 18
  1. c-ANCA, cytoplasmic antineutrophil cytoplasmic antibody; ENT, ear nose and throat; GIT, gastrointestinal tract; MPO, myeloperoxidase; p-ANCA, perinuclear antineutrophil cytoplasmic antibody; PR3, proteinase 3