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Table 2 Assessment of in vitro drug interactions against L. major (5ASKH strain) promastigotes

From: In vitro screening of known drugs identified by scaffold hopping techniques shows promising leishmanicidal activity for suramin and netilmicin

Serial no.

Drug combination

Mean \(\sum {\text{FICs}}\)a

Nature of the interaction

1

Paromomycin–suramin

0.41 ± 0.05

Synergism

2

Netilmicin–suramin

0.69 ± 0.29

Indifference

3

Primaquine–suramin

0.90 ± 0.08

Indifference

4

Primaquine–netilmicin

1.14 ± 0.2

Indifference

5

Primaquine–paromomycin

1.68 ± 0.15

Indifference

6

Paromomycin–netilmicin

2.6 ± 0.4

Indifference

  1. Results are given as mean ± SD of three independent experiments
  2. aMean of \(\sum {\text{FICs}}\) were used to define the nature of the interactions between the drugs against L. major (5ASKH strain) promastigotes
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