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Table 2 Association of CK 5/6 expression with clinicopathologic features of triple negative breast cancer

From: Cytokeratin 5/6 and cytokeratin 8/18 expression in triple negative breast cancers: clinicopathologic significance in South-Asian population

 

n (%)

P-value

No loss of expression (n = 12)

Complete loss of expression (n = 4)

Focal loss of expression (n = 134)

Total (n = 150)

Age groups (years)

 ≤ 30

0 (0)

0 (0)

5 (3.7)

5 (3.3)

0.907

 31–50

8 (66.7)

2 (50)

74 (55.2)

84 (56)

 > 50

4 (33.3)

2 (50)

55 (41)

61 (40.7)

Tumor stage

 T1

1 (8.3)

0 (0)

25 (18.7)

26 (17.3)

0.690

 T2

6 (50)

2 (50)

71 (53)

79 (52.7)

 T3/T4

5 (41.7)

2 (50)

38 (28.4)

45 (30)

ki67 index groups (%)

 ≤ 15

3 (25)

1 (25)

13 (9.7)

17 (11.3)

0.272

 16–24

0 (0)

0 (0)

8 (6)

8 (5.3)

 25–44

1 (8.3)

1 (25)

43 (32.1)

45 (30)

 > 44

8 (66.7)

2 (50)

70 (52.2)

80 (53.3)

Nodal status

 Positive

4 (33.3)

2 (50)

58 (43.3)

64 (42.7)

0.763

 Negative

8 (66.7)

2 (50)

76 (56.7)

86 (57.3)

Nodal stage

 No

8 (66.7)

2 (50)

78 (58.2)

88 (58.7)

0.232

 N1

1 (8.3)

1 (25)

28 (20.9)

30 (20)

 N2

3 (25)

0 (0)

10 (7.5)

13 (8.7)

 N3

0 (0)

1 (25)

18 (13.4)

19 (12.7)

Histological subtypes

 IDC

9 (75)

4 (100)

114 (85.1)

127 (84.7)

0.419

 Papillary

0 (0)

0 (0)

6 (4.5)

6 (4)

 Medullary

0 (0)

0 (0)

1 (0.7)

1 (0.7)

 Metaplastic

2 (16.7)

0 (0)

12 (9)

14 (9.3)

 Mixed

1 (8.3)

0 (0)

1 (0.7)

2 (1.3)

Tumor grade

 Grade-I

0 (0)

0 (0)

1 (0.7)

1 (0.7)

1.000

 Grade-II

1 (8.3)

0 (0)

18 (13.4)

19 (12.7)

 Grade-III

11 (91.7)

4 (100)

115 (85.8)

130 (86.7)

Lymphocytic infiltration

 Absent

0 (0)

0 (0)

15 (11.2)

15 (10)

0.689

 Moderate

9 (75)

4 (100)

97 (72.4)

110 (73.3)

 Severe

3 (25)

0(0)

22 (16.4)

25 (16.7)

Lymphovascular invasion

 Present

1 (8.3)

1 (25)

34 (25.4)

36 (24)

0.466

 Absent

11 (91.7)

3 (75)

100 (74.6)

114 (76)

Dermal lymphatic invasion

 Present

1 (8.3)

1 (25)

8 (6)

10 (6.7)

0.172

 Absent

11 (91.7)

3 (75)

126 (94)

140 (93.3)

Type of surgery

 Modified radical mastectomy

10 (83.3)

2 (50)

82 (61.2)

94 (62.7)

0.522

 Simple mastectomy with sentinel lymph node dissection

2 (16.7)

2 (50)

38 (28.4)

42 (28)

 Wide local excision

0 (0)

0 (0)

14 (10.4)

14 (9.3)

Necrosis

 Absent

2 (16.7)

1 (25)

18 (13.4)

21 (14)

0.507

 Moderate

7 (58.3)

1 (25)

82 (61.2)

90 (60)

 Severe

3 (25)

2 (50)

34 (25.4)

39 (26)

Fibrosis

 Mild

4 (33.3)

0 (0)

38 (28.4)

42 (28)

0.167

 Moderate

8 (66.7)

2 (50)

78 (58.2)

88 (58.7)

 Severe

0 (0)

2 (50)

18 (13.4)

20 (13.3)

Insitu component

 Present

2 (16.7)

3 (75)

53 (39.6)

58 (38.7)

0.098

 Absent

10 (83.3)

1 (25)

81 (60.4)

92 (61.3)

Pagetoid spread

 Present

0 (0)

0 (0)

2 (1.5)

2 (1.3)

1.000

 Absent

12 (100)

4 (100)

132 (98.5)

148 (98.7)

Perinodal extension

 Present

2 (16.7)

1 (25)

27 (20.1)

30 (20)

1.000

 Absent

10 (83.3)

3 (75)

107 (79.9)

120 (80)

  1. Chi Square test applied
  2. P-value ≤ 0.05, considered as significant