n (%) | P-value | ||||
---|---|---|---|---|---|
No loss of expression (n = 12) | Complete loss of expression (n = 4) | Focal loss of expression (n = 134) | Total (n = 150) | ||
Age groups (years) | |||||
≤ 30 | 0 (0) | 0 (0) | 5 (3.7) | 5 (3.3) | 0.907 |
31–50 | 8 (66.7) | 2 (50) | 74 (55.2) | 84 (56) | |
> 50 | 4 (33.3) | 2 (50) | 55 (41) | 61 (40.7) | |
Tumor stage | |||||
T1 | 1 (8.3) | 0 (0) | 25 (18.7) | 26 (17.3) | 0.690 |
T2 | 6 (50) | 2 (50) | 71 (53) | 79 (52.7) | |
T3/T4 | 5 (41.7) | 2 (50) | 38 (28.4) | 45 (30) | |
ki67 index groups (%) | |||||
≤ 15 | 3 (25) | 1 (25) | 13 (9.7) | 17 (11.3) | 0.272 |
16–24 | 0 (0) | 0 (0) | 8 (6) | 8 (5.3) | |
25–44 | 1 (8.3) | 1 (25) | 43 (32.1) | 45 (30) | |
> 44 | 8 (66.7) | 2 (50) | 70 (52.2) | 80 (53.3) | |
Nodal status | |||||
Positive | 4 (33.3) | 2 (50) | 58 (43.3) | 64 (42.7) | 0.763 |
Negative | 8 (66.7) | 2 (50) | 76 (56.7) | 86 (57.3) | |
Nodal stage | |||||
No | 8 (66.7) | 2 (50) | 78 (58.2) | 88 (58.7) | 0.232 |
N1 | 1 (8.3) | 1 (25) | 28 (20.9) | 30 (20) | |
N2 | 3 (25) | 0 (0) | 10 (7.5) | 13 (8.7) | |
N3 | 0 (0) | 1 (25) | 18 (13.4) | 19 (12.7) | |
Histological subtypes | |||||
IDC | 9 (75) | 4 (100) | 114 (85.1) | 127 (84.7) | 0.419 |
Papillary | 0 (0) | 0 (0) | 6 (4.5) | 6 (4) | |
Medullary | 0 (0) | 0 (0) | 1 (0.7) | 1 (0.7) | |
Metaplastic | 2 (16.7) | 0 (0) | 12 (9) | 14 (9.3) | |
Mixed | 1 (8.3) | 0 (0) | 1 (0.7) | 2 (1.3) | |
Tumor grade | |||||
Grade-I | 0 (0) | 0 (0) | 1 (0.7) | 1 (0.7) | 1.000 |
Grade-II | 1 (8.3) | 0 (0) | 18 (13.4) | 19 (12.7) | |
Grade-III | 11 (91.7) | 4 (100) | 115 (85.8) | 130 (86.7) | |
Lymphocytic infiltration | |||||
Absent | 0 (0) | 0 (0) | 15 (11.2) | 15 (10) | 0.689 |
Moderate | 9 (75) | 4 (100) | 97 (72.4) | 110 (73.3) | |
Severe | 3 (25) | 0(0) | 22 (16.4) | 25 (16.7) | |
Lymphovascular invasion | |||||
Present | 1 (8.3) | 1 (25) | 34 (25.4) | 36 (24) | 0.466 |
Absent | 11 (91.7) | 3 (75) | 100 (74.6) | 114 (76) | |
Dermal lymphatic invasion | |||||
Present | 1 (8.3) | 1 (25) | 8 (6) | 10 (6.7) | 0.172 |
Absent | 11 (91.7) | 3 (75) | 126 (94) | 140 (93.3) | |
Type of surgery | |||||
Modified radical mastectomy | 10 (83.3) | 2 (50) | 82 (61.2) | 94 (62.7) | 0.522 |
Simple mastectomy with sentinel lymph node dissection | 2 (16.7) | 2 (50) | 38 (28.4) | 42 (28) | |
Wide local excision | 0 (0) | 0 (0) | 14 (10.4) | 14 (9.3) | |
Necrosis | |||||
Absent | 2 (16.7) | 1 (25) | 18 (13.4) | 21 (14) | 0.507 |
Moderate | 7 (58.3) | 1 (25) | 82 (61.2) | 90 (60) | |
Severe | 3 (25) | 2 (50) | 34 (25.4) | 39 (26) | |
Fibrosis | |||||
Mild | 4 (33.3) | 0 (0) | 38 (28.4) | 42 (28) | 0.167 |
Moderate | 8 (66.7) | 2 (50) | 78 (58.2) | 88 (58.7) | |
Severe | 0 (0) | 2 (50) | 18 (13.4) | 20 (13.3) | |
Insitu component | |||||
Present | 2 (16.7) | 3 (75) | 53 (39.6) | 58 (38.7) | 0.098 |
Absent | 10 (83.3) | 1 (25) | 81 (60.4) | 92 (61.3) | |
Pagetoid spread | |||||
Present | 0 (0) | 0 (0) | 2 (1.5) | 2 (1.3) | 1.000 |
Absent | 12 (100) | 4 (100) | 132 (98.5) | 148 (98.7) | |
Perinodal extension | |||||
Present | 2 (16.7) | 1 (25) | 27 (20.1) | 30 (20) | 1.000 |
Absent | 10 (83.3) | 3 (75) | 107 (79.9) | 120 (80) |