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Table 2 Association of CK 5/6 expression with clinicopathologic features of triple negative breast cancer

From: Cytokeratin 5/6 and cytokeratin 8/18 expression in triple negative breast cancers: clinicopathologic significance in South-Asian population

  n (%) P-value
No loss of expression (n = 12) Complete loss of expression (n = 4) Focal loss of expression (n = 134) Total (n = 150)
Age groups (years)
 ≤ 30 0 (0) 0 (0) 5 (3.7) 5 (3.3) 0.907
 31–50 8 (66.7) 2 (50) 74 (55.2) 84 (56)
 > 50 4 (33.3) 2 (50) 55 (41) 61 (40.7)
Tumor stage
 T1 1 (8.3) 0 (0) 25 (18.7) 26 (17.3) 0.690
 T2 6 (50) 2 (50) 71 (53) 79 (52.7)
 T3/T4 5 (41.7) 2 (50) 38 (28.4) 45 (30)
ki67 index groups (%)
 ≤ 15 3 (25) 1 (25) 13 (9.7) 17 (11.3) 0.272
 16–24 0 (0) 0 (0) 8 (6) 8 (5.3)
 25–44 1 (8.3) 1 (25) 43 (32.1) 45 (30)
 > 44 8 (66.7) 2 (50) 70 (52.2) 80 (53.3)
Nodal status
 Positive 4 (33.3) 2 (50) 58 (43.3) 64 (42.7) 0.763
 Negative 8 (66.7) 2 (50) 76 (56.7) 86 (57.3)
Nodal stage
 No 8 (66.7) 2 (50) 78 (58.2) 88 (58.7) 0.232
 N1 1 (8.3) 1 (25) 28 (20.9) 30 (20)
 N2 3 (25) 0 (0) 10 (7.5) 13 (8.7)
 N3 0 (0) 1 (25) 18 (13.4) 19 (12.7)
Histological subtypes
 IDC 9 (75) 4 (100) 114 (85.1) 127 (84.7) 0.419
 Papillary 0 (0) 0 (0) 6 (4.5) 6 (4)
 Medullary 0 (0) 0 (0) 1 (0.7) 1 (0.7)
 Metaplastic 2 (16.7) 0 (0) 12 (9) 14 (9.3)
 Mixed 1 (8.3) 0 (0) 1 (0.7) 2 (1.3)
Tumor grade
 Grade-I 0 (0) 0 (0) 1 (0.7) 1 (0.7) 1.000
 Grade-II 1 (8.3) 0 (0) 18 (13.4) 19 (12.7)
 Grade-III 11 (91.7) 4 (100) 115 (85.8) 130 (86.7)
Lymphocytic infiltration
 Absent 0 (0) 0 (0) 15 (11.2) 15 (10) 0.689
 Moderate 9 (75) 4 (100) 97 (72.4) 110 (73.3)
 Severe 3 (25) 0(0) 22 (16.4) 25 (16.7)
Lymphovascular invasion
 Present 1 (8.3) 1 (25) 34 (25.4) 36 (24) 0.466
 Absent 11 (91.7) 3 (75) 100 (74.6) 114 (76)
Dermal lymphatic invasion
 Present 1 (8.3) 1 (25) 8 (6) 10 (6.7) 0.172
 Absent 11 (91.7) 3 (75) 126 (94) 140 (93.3)
Type of surgery
 Modified radical mastectomy 10 (83.3) 2 (50) 82 (61.2) 94 (62.7) 0.522
 Simple mastectomy with sentinel lymph node dissection 2 (16.7) 2 (50) 38 (28.4) 42 (28)
 Wide local excision 0 (0) 0 (0) 14 (10.4) 14 (9.3)
Necrosis
 Absent 2 (16.7) 1 (25) 18 (13.4) 21 (14) 0.507
 Moderate 7 (58.3) 1 (25) 82 (61.2) 90 (60)
 Severe 3 (25) 2 (50) 34 (25.4) 39 (26)
Fibrosis
 Mild 4 (33.3) 0 (0) 38 (28.4) 42 (28) 0.167
 Moderate 8 (66.7) 2 (50) 78 (58.2) 88 (58.7)
 Severe 0 (0) 2 (50) 18 (13.4) 20 (13.3)
Insitu component
 Present 2 (16.7) 3 (75) 53 (39.6) 58 (38.7) 0.098
 Absent 10 (83.3) 1 (25) 81 (60.4) 92 (61.3)
Pagetoid spread
 Present 0 (0) 0 (0) 2 (1.5) 2 (1.3) 1.000
 Absent 12 (100) 4 (100) 132 (98.5) 148 (98.7)
Perinodal extension
 Present 2 (16.7) 1 (25) 27 (20.1) 30 (20) 1.000
 Absent 10 (83.3) 3 (75) 107 (79.9) 120 (80)
  1. Chi Square test applied
  2. P-value ≤ 0.05, considered as significant