TY - JOUR AU - Leira, R. AU - Davalos, A. AU - Silva, Y. AU - Gil-Peralta, A. AU - Tejada, J. AU - Garcia, M. PY - 2004 DA - 2004// TI - Early neurologic deterioration in intracerebral hemorrhage: predictors and associated factors JO - Neurology VL - 63 UR - https://doi.org/10.1212/01.WNL.0000133204.81153.AC DO - 10.1212/01.WNL.0000133204.81153.AC ID - Leira2004 ER - TY - JOUR AU - Lord, A. S. AU - Gilmore, E. AU - Choi, H. A. AU - Mayer, S. A. PY - 2015 DA - 2015// TI - Time course and predictors of neurological deterioration after intracerebral hemorrhage JO - Stroke VL - 46 UR - https://doi.org/10.1161/STROKEAHA.114.007704 DO - 10.1161/STROKEAHA.114.007704 ID - Lord2015 ER - TY - JOUR AU - Ovesen, C. AU - Christensen, A. F. AU - Havsteen, I. AU - Hansen, C. K. AU - Rosenbaum, S. AU - Kurt, E. PY - 2015 DA - 2015// TI - Prediction and prognostication of neurological deterioration in patients with acute ICH: a hospital-based cohort study JO - BMJ Open VL - 5 UR - https://doi.org/10.1136/bmjopen-2015-008563 DO - 10.1136/bmjopen-2015-008563 ID - Ovesen2015 ER - TY - JOUR AU - Davis, S. M. AU - Broderick, J. AU - Hennerici, M. AU - Brun, N. C. AU - Diringer, M. N. AU - Mayer, S. A. PY - 2006 DA - 2006// TI - Hematoma growth is a determinant of mortality and poor outcome after intracerebral hemorrhage JO - Neurology VL - 66 UR - https://doi.org/10.1212/01.wnl.0000208408.98482.99 DO - 10.1212/01.wnl.0000208408.98482.99 ID - Davis2006 ER - TY - JOUR AU - Delcourt, C. AU - Huang, Y. AU - Arima, H. AU - Chalmers, J. AU - Davis, S. M. AU - Heeley, E. L. PY - 2012 DA - 2012// TI - Hematoma growth and outcomes in intracerebral hemorrhage: the INTERACT1 study JO - Neurology VL - 79 UR - https://doi.org/10.1212/WNL.0b013e318260cbba DO - 10.1212/WNL.0b013e318260cbba ID - Delcourt2012 ER - TY - JOUR AU - Dowlatshahi, D. AU - Demchuk, A. M. AU - Flaherty, M. L. AU - Ali, M. AU - Lyden, P. L. AU - Smith, E. E. PY - 2011 DA - 2011// TI - Defining hematoma expansion in intracerebral hemorrhage: relationship with patient outcomes JO - Neurology VL - 76 UR - https://doi.org/10.1212/WNL.0b013e3182143317 DO - 10.1212/WNL.0b013e3182143317 ID - Dowlatshahi2011 ER - TY - JOUR AU - Steiner, T. AU - Diringer, M. N. AU - Schneider, D. AU - Mayer, S. A. AU - Begtrup, K. AU - Broderick, J. PY - 2006 DA - 2006// TI - Dynamics of intraventricular hemorrhage in patients with spontaneous intracerebral hemorrhage: risk factors, clinical impact, and effect of hemostatic therapy with recombinant activated factor VII JO - Neurosurgery VL - 59 UR - https://doi.org/10.1227/01.NEU.0000232837.34992.32 DO - 10.1227/01.NEU.0000232837.34992.32 ID - Steiner2006 ER - TY - JOUR AU - Moullaali, T. J. AU - Sato, S. AU - Wang, X. AU - Rabinstein, A. A. AU - Arima, H. AU - Carcel, C. PY - 2017 DA - 2017// TI - Prognostic significance of delayed intraventricular haemorrhage in the INTERACT studies JO - J Neurol Neurosurg Psychiatry VL - 88 UR - https://doi.org/10.1136/jnnp-2015-311562 DO - 10.1136/jnnp-2015-311562 ID - Moullaali2017 ER - TY - JOUR AU - Maas, M. B. AU - Nemeth, A. J. AU - Rosenberg, N. F. AU - Kosteva, A. R. AU - Prabhakaran, S. AU - Naidech, A. M. PY - 2013 DA - 2013// TI - Delayed intraventricular hemorrhage is common and worsens outcomes in intracerebral hemorrhage JO - Neurology VL - 80 UR - https://doi.org/10.1212/WNL.0b013e31828ab2a7 DO - 10.1212/WNL.0b013e31828ab2a7 ID - Maas2013 ER - TY - JOUR AU - Witsch, J. AU - Bruce, E. AU - Meyers, E. AU - Velazquez, A. AU - Schmidt, J. M. AU - Suwatcharangkoon, S. PY - 2015 DA - 2015// TI - Intraventricular hemorrhage expansion in patients with spontaneous intracerebral hemorrhage JO - Neurology VL - 84 UR - https://doi.org/10.1212/WNL.0000000000001344 DO - 10.1212/WNL.0000000000001344 ID - Witsch2015 ER - TY - JOUR AU - Sprigg, N. AU - Robson, K. AU - Bath, P. AU - Dineen, R. AU - Roberts, I. AU - Robinson, T. PY - 2016 DA - 2016// TI - Intravenous tranexamic acid for hyperacute primary intracerebral hemorrhage: protocol for a randomized, placebo-controlled trial JO - Int J Stroke VL - 11 UR - https://doi.org/10.1177/1747493016641960 DO - 10.1177/1747493016641960 ID - Sprigg2016 ER - TY - JOUR AU - Mayer, S. A. AU - Brun, N. C. AU - Begtrup, K. AU - Broderick, J. AU - Davis, S. AU - Diringer, M. N. PY - 2008 DA - 2008// TI - Efficacy and safety of recombinant activated factor VII for acute intracerebral hemorrhage JO - N Engl J Med VL - 358 UR - https://doi.org/10.1056/NEJMoa0707534 DO - 10.1056/NEJMoa0707534 ID - Mayer2008 ER - TY - JOUR AU - Mayer, S. A. AU - Davis, S. M. AU - Skolnick, B. E. AU - Brun, N. C. AU - Begtrup, K. AU - Broderick, J. P. PY - 2009 DA - 2009// TI - Can a subset of intracerebral hemorrhage patients benefit from hemostatic therapy with recombinant activated factor VII? JO - Stroke VL - 40 UR - https://doi.org/10.1161/STROKEAHA.108.524470 DO - 10.1161/STROKEAHA.108.524470 ID - Mayer2009 ER - TY - JOUR PY - 2010 DA - 2010// TI - Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial JO - Lancet VL - 376 UR - https://doi.org/10.1016/S0140-6736(10)60835-5 DO - 10.1016/S0140-6736(10)60835-5 ID - ref14 ER - TY - JOUR AU - Kang, D. W. AU - Han, M. K. AU - Kim, H. J. AU - Yun, S. C. AU - Jeon, S. B. AU - Bae, H. J. PY - 2012 DA - 2012// TI - New ischemic lesions coexisting with acute intracerebral hemorrhage JO - Neurology VL - 79 UR - https://doi.org/10.1212/WNL.0b013e3182648a79 DO - 10.1212/WNL.0b013e3182648a79 ID - Kang2012 ER - TY - JOUR AU - Menon, R. S. AU - Burgess, R. E. AU - Wing, J. J. AU - Gibbons, M. C. AU - Shara, N. M. AU - Fernandez, S. PY - 2012 DA - 2012// TI - Predictors of highly prevalent brain ischemia in intracerebral hemorrhage JO - Ann Neurol VL - 71 UR - https://doi.org/10.1002/ana.22668 DO - 10.1002/ana.22668 ID - Menon2012 ER - TY - JOUR AU - Du, F. Z. AU - Jiang, R. AU - Gu, M. AU - He, C. AU - Guan, J. PY - 2014 DA - 2014// TI - The accuracy of spot sign in predicting hematoma expansion after intracerebral hemorrhage: a systematic review and meta-analysis JO - PLoS ONE VL - 9 UR - https://doi.org/10.1371/journal.pone.0115777 DO - 10.1371/journal.pone.0115777 ID - Du2014 ER - TY - JOUR AU - Giudice, A. AU - D’Amico, D. AU - Sobesky, J. AU - Wellwood, I. PY - 2014 DA - 2014// TI - Accuracy of the spot sign on computed tomography angiography as a predictor of haematoma enlargement after acute spontaneous intracerebral haemorrhage: a systematic review JO - Cerebrovasc Dis VL - 37 UR - https://doi.org/10.1159/000360754 DO - 10.1159/000360754 ID - Giudice2014 ER - TY - JOUR AU - Rodriguez-Luna, D. AU - Dowlatshahi, D. AU - Aviv, R. I. AU - Molina, C. A. AU - Silva, Y. AU - Dzialowski, I. PY - 2014 DA - 2014// TI - Venous phase of computed tomography angiography increases spot sign detection, but intracerebral hemorrhage expansion is greater in spot signs detected in arterial phase JO - Stroke VL - 45 UR - https://doi.org/10.1161/STROKEAHA.113.003007 DO - 10.1161/STROKEAHA.113.003007 ID - Rodriguez-Luna2014 ER - TY - JOUR AU - Ederies, A. AU - Demchuk, A. AU - Chia, T. AU - Gladstone, D. J. AU - Dowlatshahi, D. AU - Bendavit, G. PY - 2009 DA - 2009// TI - Postcontrast CT extravasation is associated with hematoma expansion in CTA spot negative patients JO - Stroke VL - 40 UR - https://doi.org/10.1161/STROKEAHA.108.541201 DO - 10.1161/STROKEAHA.108.541201 ID - Ederies2009 ER - TY - JOUR AU - Hallevi, H. AU - Abraham, A. T. AU - Barreto, A. D. AU - Grotta, J. C. AU - Savitz, S. I. PY - 2010 DA - 2010// TI - The spot sign in intracerebral hemorrhage: the importance of looking for contrast extravasation JO - Cerebrovasc Dis VL - 29 UR - https://doi.org/10.1159/000267842 DO - 10.1159/000267842 ID - Hallevi2010 ER - TY - JOUR AU - Flaherty, K. AU - Bath, P. M. AU - Dineen, R. AU - Law, Z. AU - Scutt, P. AU - Pocock, S. PY - 2017 DA - 2017// TI - Statistical analysis plan for the ‘Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage’ (TICH-2) trial JO - Trials VL - 18 UR - https://doi.org/10.1186/s13063-017-2341-5 DO - 10.1186/s13063-017-2341-5 ID - Flaherty2017 ER - TY - JOUR AU - Wada, R. AU - Aviv, R. I. AU - Fox, A. J. AU - Sahlas, D. J. AU - Gladstone, D. J. AU - Tomlinson, G. PY - 2007 DA - 2007// TI - CT angiography “spot sign” predicts hematoma expansion in acute intracerebral hemorrhage JO - Stroke VL - 38 UR - https://doi.org/10.1161/01.STR.0000259633.59404.f3 DO - 10.1161/01.STR.0000259633.59404.f3 ID - Wada2007 ER - TY - STD TI - Luedicke J. powersim - Stata module for simulation-based power analysis for linear and generalized linear models. 2013. http://fmwww.bc.edu/RePEc/bocode/p/powersim_tutorial.pdf. Accessed 6 June 2018. UR - http://fmwww.bc.edu/RePEc/bocode/p/powersim_tutorial.pdf ID - ref24 ER - TY - JOUR AU - Poon, M. T. AU - Fonville, A. F. AU - Al-Shahi Salman, R. PY - 2014 DA - 2014// TI - Long-term prognosis after intracerebral haemorrhage: systematic review and meta-analysis JO - J Neurol Neurosurg Psychiatry VL - 85 UR - https://doi.org/10.1136/jnnp-2013-306476 DO - 10.1136/jnnp-2013-306476 ID - Poon2014 ER - TY - JOUR AU - Vickers, A. J. PY - 2001 DA - 2001// TI - The use of percentage change from baseline as an outcome in a controlled trial is statistically inefficient: a simulation study JO - BMC Med Res Methodol VL - 1 UR - https://doi.org/10.1186/1471-2288-1-6 DO - 10.1186/1471-2288-1-6 ID - Vickers2001 ER - TY - JOUR AU - Vickers, A. J. AU - Altman, D. G. PY - 2001 DA - 2001// TI - Statistics notes: analysing controlled trials with baseline and follow up measurements JO - BMJ VL - 323 UR - https://doi.org/10.1136/bmj.323.7321.1123 DO - 10.1136/bmj.323.7321.1123 ID - Vickers2001 ER - TY - JOUR AU - Localio, A. R. AU - Berlin, J. A. AU - Have, T. R. AU - Kimmel, S. E. PY - 2001 DA - 2001// TI - Adjustments for center in multicenter studies: an overview JO - Ann Intern Med VL - 135 UR - https://doi.org/10.7326/0003-4819-135-2-200107170-00012 DO - 10.7326/0003-4819-135-2-200107170-00012 ID - Localio2001 ER - TY - JOUR AU - Kahan, B. C. AU - Harhay, M. O. PY - 2015 DA - 2015// TI - Many multicenter trials had few events per center, requiring analysis via random-effects models or GEEs JO - J Clin Epidemiol VL - 68 UR - https://doi.org/10.1016/j.jclinepi.2015.03.016 DO - 10.1016/j.jclinepi.2015.03.016 ID - Kahan2015 ER - TY - JOUR AU - Kahan, B. C. PY - 2014 DA - 2014// TI - Accounting for centre-effects in multicentre trials with a binary outcome—when, why, and how? JO - BMC Med Res Methodol VL - 14 UR - https://doi.org/10.1186/1471-2288-14-20 DO - 10.1186/1471-2288-14-20 ID - Kahan2014 ER - TY - JOUR AU - Oxman, A. D. AU - Guyatt, G. H. PY - 1992 DA - 1992// TI - A consumer’s guide to subgroup analyses JO - Ann Intern Med VL - 116 UR - https://doi.org/10.7326/0003-4819-116-1-78 DO - 10.7326/0003-4819-116-1-78 ID - Oxman1992 ER - TY - JOUR AU - Assmann, S. F. AU - Pocock, S. J. AU - Enos, L. E. AU - Kasten, L. E. PY - 2000 DA - 2000// TI - Subgroup analysis and other (mis)uses of baseline data in clinical trials JO - Lancet VL - 355 UR - https://doi.org/10.1016/S0140-6736(00)02039-0 DO - 10.1016/S0140-6736(00)02039-0 ID - Assmann2000 ER - TY - JOUR AU - Brookes, S. T. AU - Whitely, E. AU - Egger, M. AU - Smith, G. D. AU - Mulheran, P. A. AU - Peters, T. J. PY - 2004 DA - 2004// TI - Subgroup analyses in randomized trials: risks of subgroup-specific analyses; power and sample size for the interaction test JO - J Clin Epidemiol VL - 57 UR - https://doi.org/10.1016/j.jclinepi.2003.08.009 DO - 10.1016/j.jclinepi.2003.08.009 ID - Brookes2004 ER - TY - JOUR AU - Liu, L. AU - Wang, Y. AU - Meng, X. AU - Li, N. AU - Tan, Y. AU - Nie, X. PY - 2017 DA - 2017// TI - Tranexamic acid for acute intracerebral hemorrhage growth predicted by spot sign trial: rationale and design JO - Int J Stroke VL - 12 UR - https://doi.org/10.1177/1747493017694394 DO - 10.1177/1747493017694394 ID - Liu2017 ER - TY - JOUR AU - Meretoja, A. AU - Churilov, L. AU - Campbell, B. C. AU - Aviv, R. I. AU - Yassi, N. AU - Barras, C. PY - 2014 DA - 2014// TI - The spot sign and tranexamic acid on preventing ICH growth–AUStralasia Trial (STOP-AUST): protocol of a phase II randomized, placebo-controlled, double-blind, multicenter trial JO - Int J Stroke VL - 9 UR - https://doi.org/10.1111/ijs.12132 DO - 10.1111/ijs.12132 ID - Meretoja2014 ER - TY - JOUR AU - Law, Z. K. AU - Meretoja, A. AU - Engelter, S. T. AU - Christensen, H. AU - Muresan, E. AU - Glad, S. B. PY - 2016 DA - 2016// TI - Treatment of intracerebral haemorrhage with tranexamic acid—a review of current evidence and ongoing trials JO - Eur Stroke J VL - 2 UR - https://doi.org/10.1177/2396987316676610 DO - 10.1177/2396987316676610 ID - Law2016 ER - TY - JOUR AU - Jakobsen, J. C. AU - Gluud, C. AU - Winkel, P. AU - Lange, T. AU - Wetterslev, J. PY - 2014 DA - 2014// TI - The thresholds for statistical and clinical significance—a five-step procedure for evaluation of intervention effects in randomised clinical trials JO - BMC Med Res Methodol VL - 14 UR - https://doi.org/10.1186/1471-2288-14-34 DO - 10.1186/1471-2288-14-34 ID - Jakobsen2014 ER - TY - JOUR AU - Sprigg, N. AU - Flaherty, K. AU - Appleton, J. P. AU - Salman, R. A. AU - Bereczki, D. AU - Beridze, M. PY - 2018 DA - 2018// TI - Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial JO - Lancet UR - https://doi.org/10.1016/S0140-6736(18)31033-X DO - 10.1016/S0140-6736(18)31033-X ID - Sprigg2018 ER -