Fig. 1

Time course study of the effect of tegaserod (5 mg/kg, i.p.) on the expression levels of GRK2 and GRK6 in the rat digestive tract. a GRK2 levels in the oesophagus; b GRK2 levels in the distal colon; and c GRK6 levels in the oesophagus. Upper panels: representative immunoblots illustrating the effects of tegaserod on the expression level of GRK2 or GRK6 at 1, 2, 3, 4, 6 and 8 h after treatment. Lower panels: the mean densitometric values of GRK2 or GRK6 levels relative to β-actin and expressed as percentages of values in untreated control rats (± SEM, n = 6 per group). No significant difference from the control occurred in any of the treatments (P > 0.05; one-way ANOVA). Con control, h hours following treatment