Genetic screen identifies a requirement for SMN in mRNA localisation within the Drosophila oocyte

BMC Research Notes

Table 1 Chromosome deficiency lines that depress the viability of SMN^7Ao heterozygotes

Chromosome	Deficiency	Deleted region	Deleted genes	% Flies eclosed mean ± SEM	Previously identified modifiers^a	Interaction strength
2L	Df(2L)BSC37	22D1–22F2	74	84.1 ± 0.5	tho2	+
2L	Df(2L)ed1	24A2–24D4	66	76.7 ± 6.3	–	+
2L	Df(2L)BSC5	26B1–26D2	79	79.9 ± 5.4	eIF4A	+
2L	Df(2L)cact-255rv64	35F6–36D	181	83.1 ± 1.7	VhaSFD, Tpr2, Sytα	+
3L	Df(3L)HR119	63C6–63F7	75	81.5 ± 7.8	enc, PIG-C, CG12016, PIG-B, CG32262, CG32263, CG32264, Rdh, CG42456	+
3L	Df(3L)h-i22	66D10–66E2	29	66 ± 6.7	–	++
3L	Df(3L)vin5	68A2–69A1	239	71.1 ± 1.4	Sod1, CG14130, Alg10, NaPi-III	++
3L	Df(3L)81k19	73A3–74F4	175	0	SMN	++++
3R	Df(3R)WIN11	83E1–84A5	107	70.3 ± 8.7	Dmtn	++
3R	Df(3R)T-32	86D9–87C4	241	59.4 ± 7.2	svp, GstD3, Cyp313a2, Jupiter, Csk	+++
3R	Df(3R)BSC43	92F7–93B6	54	81.4 ± 3	Syp, CG17272	+
3R	Df(3R)B81	99D3–3Rt	280	48 ± 0.6	heph, aralar1, CG9682, mRpL32, CG1750	++++

^aGenetic modifiers previously identified in the Chang et al. [7] and Sen et al. [10] studies

ISSN: 1756-0500