Fig. 1

A formal description of the graph representation and workflow used by GrapHi-C. a The mathematical model used to represent a contact map as an undirected graph in the GrapHi-C protocol. b Overview of the GrapHi-C protocol. Each step of the workflow is indicated in a box where the different colours correspond to: data input and output (grey), developed Perl script (purple), and an existing tool (orange). An option for scaling the interaction frequencies is available in the developed Perl script if future studies wish to use it