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Table 2 Association of p53 over expression categories with clinic pathologic parameters of head and neck Squamous cell carcinoma

From: Immunohistochemical over expression of p53 in head and neck Squamous cell carcinoma: clinical and prognostic significance

  n (%) P value Power of test (%)
≤ 10% (n = 43) 11–50% (n = 23) 51–70% (n = 23) > 70% (n = 32) Total (n = 121)
Age group (years)
 ≤ 30 3 (7) 0 (0) 1 (4.3) 1 (3.1) 5 (4.1) 0.502 37.12
 31–50 23 (53.5) 8 (34.8) 10 (43.5) 17 (53.1) 58 (47.9)
 > 50 17 (39.5) 15 (65.2) 12 (52.2) 14 (43.8) 58 (47.9)
Gender
 Male 36 (83.7) 15 (65.2) 16 (69.6) 22 (68.8) 89 (73.6) 0.299 33.12
 Female 7 (16.3) 8 (34.8) 7 (30.4) 10 (31.3) 32 (26.4)
Depth of invasion (cm)
 < 2 36 (83.7) 17 (73.9) 23 (100) 26 (81.3) 102 (84.3) 0.056 54.7
 ≥ 2 7 (16.3) 6 (26.1) 0 (0) 6 (18.8) 19 (15.7)
Nodal stage
 N0 26 (60.5) 16 (69.6) 12 (52.2) 13 (40.6) 67 (55.4) 0.258 65.64
 N1 8 (18.6) 1 (4.3) 3 (13) 6 (18.8) 18 (14.9)
 N2a 0 (0) 0 (0) 0 (0) 0 (0) 0 (0)
 N2b 9 (20.9) 5 (21.7) 7 (30.4) 11 (34.4) 32 (26.4)
 N2c 0 (0) 0 (0) 1 (4.3) 2 (6.3) 3 (2.5)
 N3 0 (0) 1 (4.3) 0 (0) 0 (0) 1 (0.8)
Histological subtypes
 Non-keratinizing 3 (7) 1 (4.3) 4 (17.4) 10 (31.3) 18 (14.9) 0.100 71.32
 Keratinizing 28 (65.1) 15 (65.2) 12 (52.2) 14 (43.8) 69 (57)
 Non-keratinizing with maturation 12 (27.9) 7 (30.4) 7 (30.4) 8 (25) 34 (28.1)
Histologic grade
 Grade-I 13 (30.2) 11 (47.8) 5 (21.7) 4 (12.5) 33 (27.3) 0.065 74.37
 Grade-II 24 (55.8) 11 (47.8) 13 (56.5) 25 (78.1) 73 (60.3)
 Grade-III 6 (14) 1 (4.3) 5 (21.7) 3 (9.4) 15 (12.4)
Perineural invasion
 Not present 39 (90.7) 22 (95.7) 21 (91.3) 23 (71.9) 105 (86.8) 0.051 69.81
 Present 4 (9.3) 1 (4.3) 2 (8.7) 9 (28.1) 16 (13.2)
  1. Chi square test was applied
  2. P-value ≤ 0.05 considered as significant