Table 2 Association of p53 over expression categories with clinic pathologic parameters of head and neck Squamous cell carcinoma
n (%) | P value | Power of test (%) | |||||
|---|---|---|---|---|---|---|---|
≤ 10% (n = 43) | 11–50% (n = 23) | 51–70% (n = 23) | > 70% (n = 32) | Total (n = 121) | |||
Age group (years) | |||||||
≤ 30 | 3 (7) | 0 (0) | 1 (4.3) | 1 (3.1) | 5 (4.1) | 0.502 | 37.12 |
31–50 | 23 (53.5) | 8 (34.8) | 10 (43.5) | 17 (53.1) | 58 (47.9) | ||
> 50 | 17 (39.5) | 15 (65.2) | 12 (52.2) | 14 (43.8) | 58 (47.9) | ||
Gender | |||||||
Male | 36 (83.7) | 15 (65.2) | 16 (69.6) | 22 (68.8) | 89 (73.6) | 0.299 | 33.12 |
Female | 7 (16.3) | 8 (34.8) | 7 (30.4) | 10 (31.3) | 32 (26.4) | ||
Depth of invasion (cm) | |||||||
< 2 | 36 (83.7) | 17 (73.9) | 23 (100) | 26 (81.3) | 102 (84.3) | 0.056 | 54.7 |
≥ 2 | 7 (16.3) | 6 (26.1) | 0 (0) | 6 (18.8) | 19 (15.7) | ||
Nodal stage | |||||||
N0 | 26 (60.5) | 16 (69.6) | 12 (52.2) | 13 (40.6) | 67 (55.4) | 0.258 | 65.64 |
N1 | 8 (18.6) | 1 (4.3) | 3 (13) | 6 (18.8) | 18 (14.9) | ||
N2a | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | ||
N2b | 9 (20.9) | 5 (21.7) | 7 (30.4) | 11 (34.4) | 32 (26.4) | ||
N2c | 0 (0) | 0 (0) | 1 (4.3) | 2 (6.3) | 3 (2.5) | ||
N3 | 0 (0) | 1 (4.3) | 0 (0) | 0 (0) | 1 (0.8) | ||
Histological subtypes | |||||||
Non-keratinizing | 3 (7) | 1 (4.3) | 4 (17.4) | 10 (31.3) | 18 (14.9) | 0.100 | 71.32 |
Keratinizing | 28 (65.1) | 15 (65.2) | 12 (52.2) | 14 (43.8) | 69 (57) | ||
Non-keratinizing with maturation | 12 (27.9) | 7 (30.4) | 7 (30.4) | 8 (25) | 34 (28.1) | ||
Histologic grade | |||||||
Grade-I | 13 (30.2) | 11 (47.8) | 5 (21.7) | 4 (12.5) | 33 (27.3) | 0.065 | 74.37 |
Grade-II | 24 (55.8) | 11 (47.8) | 13 (56.5) | 25 (78.1) | 73 (60.3) | ||
Grade-III | 6 (14) | 1 (4.3) | 5 (21.7) | 3 (9.4) | 15 (12.4) | ||
Perineural invasion | |||||||
Not present | 39 (90.7) | 22 (95.7) | 21 (91.3) | 23 (71.9) | 105 (86.8) | 0.051 | 69.81 |
Present | 4 (9.3) | 1 (4.3) | 2 (8.7) | 9 (28.1) | 16 (13.2) | ||