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Table 3 Association of p53 expression intensity with clinicopathologic parameters of head and neck Squamous cell carcinoma

From: Immunohistochemical over expression of p53 in head and neck Squamous cell carcinoma: clinical and prognostic significance

  n (%) P-value Power of test (%)
No intensity (n = 30) Weak (n = 13) Intermediate (n = 30) Strong (n = 48) Total (n = 121)
Age group (years)
 ≤ 30 3 (10) 0 (0) 1 (3.3) 1 (2.1) 5 (4.1) 0.445 43.47
 31–50 15 (50) 8 (61.5) 11 (36.7) 24 (50) 58 (47.9)
 > 50 12 (40) 5 (38.5) 18 (60) 23 (47.9) 58 (47.9)
Gender
 Male 25 (83.3) 11 (84.6) 22 (73.3) 31 (64.6) 89 (73.6) 0.269 38.17
 Female 5 (16.7) 2 (15.4) 8 (26.7) 17 (35.4) 32 (26.4)
Nodal stage
 N0 17 (56.7) 9 (69.2) 22 (73.3) 19 (39.6) 67 (55.4) 0.053 82.44
 N1 8 (26.7) 0 (0) 2 (6.7) 8 (16.7) 18 (14.9)
 N2a 0 (0) 0 (0) 0 (0) 0 (0) 0 (0)
 N2b 5 (16.7) 4 (30.8) 6 (20) 17 (35.4) 32 (26.4)
 N2c 0 (0) 0 (0) 0 (0) 3 (6.3) 3 (2.5)
 N3 0 (0) 0 (0) 0 (0) 1 (2.1) 1 (0.8)
Extranodal extension
 Not present 22 (73.3) 11 (84.6) 28 (93.3) 29 (60.4) 90 (74.4) 0.008 81.53
 Present 8 (26.7) 2 (15.4) 2 (6.7) 19 (39.6) 31 (25.6)
Histologic grade
 Grade-I 6 (20) 7 (53.8) 12 (40) 8 (16.7) 33 (27.3) 0.046 74.91
 Grade-II 20 (66.7) 4 (30.8) 14 (46.7) 35 (72.9) 73 (60.3)
 Grade-III 4 (13.3) 2 (15.4) 4 (13.3) 5 (10.4) 15 (12.4)
  1. Chi square test was applied
  2. P-value ≤ 0.05 considered as significant