Fig. 3
From: Deterioration of alveolar development in mice with both HIF-3α knockout and HIF-2α knockdown
The double-mutant mouse lung exhibited depressed expressions of HIF-1α, VCAM-1, VE-cadherin, Ang-2, Tie-2, and VEGF. The utilizing qPCR performed the analysis of mRNA relative expressions for HIF-1α, HIF-2α, VCAM-1, VE-cadherin, Ang-1, Ang-2, Tie-2, VGEF, and Flk-1 that normalized to β-actin. Ang-1, angiopoietin 1; Ang-2, angiopoietin 2; H3, hypoxia-inducible factor 3α; H2, hypoxia-inducible factor 2α; ::, intercrossed with; −/−, knockout; kd/kd, knockdown; HIF-1α, hypoxia-inducible factor 1α; HIF-2α, hypoxia-inducible factor 2α; mRNA, messenger ribonucleic acid; VCAM-1, vascular cell adhesion molecule 1; VE-cadherin, vascular endothelial cadherin; VEGF, vascular endothelial growth factor; WT, wild-type