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Fig. 1 | BMC Research Notes

Fig. 1

From: Caveolin-1 is dispensable for early lymphoid development, but plays a role in the maintenance of the mature splenic microenvironment

Fig. 1

Caveolin-1 deficiency is associated with splenomegaly with implications for Caveolin-1 as haploinsufficient for splenic B-cell maintenance. a Line graph of mean body weight (g) of Cav1+/+ (red), Cav1+/ (blue), and Cav1/ (green) mice at indicated timepoint (n = 9–22 per group). b Line graph of mean SP weight (mg) of Cav1+/+ (red), Cav1+/ (blue), and Cav1/ (green) mice at indicated timepoint (n = 9–15 per group). c (Top panel) Dot plots for CD19+CD22+ B cells in the SP for listed genotypes at 12, 24, and 36 weeks (n = 7–10 per group). (Bottom panel) Representative contour flow cytometry plots for CD19+CD22+ B cells at listed genotypes for listed timepoints. (Line graphs show mean ± SEM, dot plots show mean ± SD with each dot corresponding to a biological replicate, flow cytometry gate values show mean ± SEM, NS not significant, *p < 0.05 ANOVA and Tukey post hoc test)

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