Skip to main content

Advertisement

Table 2 Average serum and urine concentrations following single dose administration in healthy volunteers

From: Rethinking urinary antibiotic breakpoints: analysis of urinary antibiotic concentrations to treat multidrug resistant organisms

Antibacterial agent Serum Urine
Cpk (mg/L) Ctr (mg/L) Cpk (mg/L) Ctr (mg/L)
Ceftriaxone 1000 mg IV [14] 151 ND at 24 h 995 ND at 24 h
Cefepime 250 mg IV [15] 17.9 0.6 at 8 h 190 90.2 at 8 h
Cefepime 1000 mg IV [15] 65.1 2.7 at 8 h
Ciprofloxacin 500 mg PO [16] 2.46 0.22 at 12 h 394 35 at 12 h
Doripenem 500 mg IV [17] 20.2 601 49.7 at 8 h
  1. Cpk peak concentration, Ctr trough concentration, hrs hours, ND not determined