Table 2 Average serum and urine concentrations following single dose administration in healthy volunteers
Antibacterial agent | Serum | Urine | ||
|---|---|---|---|---|
Cpk (mg/L) | Ctr (mg/L) | Cpk (mg/L) | Ctr (mg/L) | |
Ceftriaxone 1000 mg IV [14] | 151 | ND at 24 h | 995 | ND at 24 h |
Cefepime 250 mg IV [15] | 17.9 | 0.6 at 8 h | 190 | 90.2 at 8 h |
Cefepime 1000 mg IV [15] | 65.1 | 2.7 at 8 h | – | – |
Ciprofloxacin 500 mg PO [16] | 2.46 | 0.22 at 12 h | 394 | 35 at 12 h |
Doripenem 500 mg IV [17] | 20.2 | – | 601 | 49.7 at 8 h |