Table 1 Association of clinico-pathologic parameters of metaplastic breast cancer subtype with Ductal carcinoma, NOS
| Â | n (%) | P-value | ||
|---|---|---|---|---|
Metaplastic | Ductal, NOS | Total | ||
Age (years)ab | 49.21 ± 12.92 | 50.54 ± 12.48 | – | 0.49 |
Age group (n = 1738) | ||||
 ≤ 30 | 3 (3.3) | 89 (5.3) | 92 (5.3) | 0.767 |
 31–50 | 21 (48.8) | 822 (48.8) | 843 (48.5) | |
 51–70 | 16 (37.2) | 692 (40.8) | 708 (40.7) | |
 > 70 | 3 (7) | 92 (5.4) | 95 (5.5) | |
Tumor grade (n = 1738) | ||||
 Grade 1 | 3 (7) | 160 (9.4) | 163 (9.4) | ≤ 0.05 |
 Grade 2 | 5 (11.6) | 945 (55.8) | 950 (54.7) | |
 Grade 3 | 35 (81.4) | 590 (34.8) | 625 (36) | |
Ki67 valueab | 40.05 ± 22.67 | 35.92 ± 23.33 | – | 0.252 |
Ki67 index category (n = 1738) | ||||
 < 15 | 4 (9.3) | 373 (22) | 377 (21.7) | 0.203 |
 15–24 | 11 (25.6) | 311 (18.3) | 322 (18.5) | |
 25–44 | 12 (27.9) | 406 (24) | 418 (24.1) | |
 > 44 | 16 (37.2) | 605 (35.7) | 621 (35.7) | |
Size of tumorab | 36.77 ± 15.31 | 36.11 ± 14.84 | – | 0.825 |
Tumor stage (n = 660) | ||||
 T1 | 4 (15.4) | 83 (13.1) | 87 (13.2) | 0.695 |
 T2 | 17 (65.4) | 454 (71.6) | 471 (71.4) | |
 T3 | 5 (19.2) | 97 (15.3) | 102 (15.5) | |
Nodal status (n = 660) | ||||
 Positive | 12 (46.2) | 318 (50.2) | 330 (50) | 0.689 |
 Negative | 14 (53.8) | 316 (48.8) | 330 (50) | |
N stage (n = 660) | ||||
 N0 | 14 (53.8) | 320 (50.5) | 334 (50.6) | 0.431 |
 N1 | 5 (19.2) | 130 (20.5) | 135 (20.5) | |
 N2 | 1 (3.8) | 85 (13.4) | 86 (13) | |
 N3 | 6 (23.1) | 99 (15.6) | 105 (15.9) | |
Laterality (n = 1738) | ||||
 Left | 19 (44.2) | 865 (51) | 884 (50.9) | 0.375 |
 Right | 24 (55.8) | 830 (49) | 854 (49.1) | |
ER (n = 1738) | ||||
 Positive | 9 (20.9) | 1019 (60.1) | 1028 (59.1) | ≤ 0.05 |
 Negative | 34 (79.1) | 676 (39.9) | 710 (40.9) | |
PR (n = 1738) | ||||
 Positive | 6 (14) | 779 (46) | 785 (45.2) | ≤ 0.05 |
 Negative | 37 (86) | 916 (54) | 953 (54.8) | |
Her2neu (n = 1738) | ||||
 Positive | 9 (20.9) | 742 (43.8) | 751 (43.2) | ≤ 0.05 |
 Negative | 34 (79.1) | 953 (56.2) | 987 (56.8) | |
Lymphocytic infiltration (n = 660) | ||||
 Absent | 10 (38.5) | 364 (57.4) | 374 (56.7) | 0.132 |
 Moderate | 13 (50) | 210 (33.1) | 223 (33.8) | |
 Severe | 3 (11.5) | 60 (9.5) | 63 (9.5) | |
Insitu component (n = 659) | ||||
 Present | 11 (42.3) | 432 (68.2) | 443 (67.2) | ≤ 0.05 |
 Absent | 15 (57.7) | 201 (31.8) | 216 (32.8) | |
Lymphovascular invasion (n = 660) | ||||
 Present | 8 (30.8) | 157 (24.8) | 165 (25) | 0.488 |
 Absent | 18 (69.2) | 477 (75.2) | 495 (75) | |
Dermal lymphatic invasion (n = 660) | ||||
 Present | 0 (0) | 78 (12.3) | 78 (11.8) | 0.061 |
 Absent | 26 (100) | 556 (87.7) | 582 (88.2) | |
Pagetoid spread (n = 660) | ||||
 Present | 0 (0) | 14 (2.2) | 14 (2.1) | 1.000 |
 Absent | 26 (100) | 620 (97.8) | 646 (97.9) | |
Molecular subtypes(n = 1738) | ||||
 Triple negative | 29 (67.4) | 298 (17.6) | 327 (18.8) | ≤ 0.05 |
 HER 2 | 5 (11.6) | 363 (21.4) | 368 (21.2) | |
 Luminal A | 1 (2.3) | 287 (16.9) | 288 (16.6) | |
 Luminal B | 8 (18.6) | 747 (44.1) | 755 (43.4) | |