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Fig. 1 | BMC Research Notes

Fig. 1

From: Analysis of hippocampal-dependent learning and memory behaviour in mice lacking Nfix from adult neural stem cells

Fig. 1

Behavioural analyses from the active place avoidance task. a Schematic of the active place avoidance (APA) testing arena. Four black and white visual cues are placed around the platform, which rotated clockwise (blue arrow). The shock zone location is shown in red. b The total number of shocks received by male (dashed line, n = 10) and female (solid line, n = 11) NfixControl mice in the APA task. c The total number of shocks received by male (red dashed line, n = 7) and female (red solid line, n = 14) NfixiNestin mice in the APA task. No significant differences were found in the number of shocks received by male and female mice of either genotype. d Time of first entry to the shock zone was not different in NfixControl mice (black) and NfixiNestin mice (red) during the APA task. e Time to second entrance into the shock zone was significantly delayed in NfixControl mice (black) compared to NfixiNestin mice (red) on day 4 of the APA task. Maximum time shock avoidance (f) and maximum path of shock avoidance (g) during the APA task was not significantly different between NfixControl mice (black) and NfixiNestin mice (red). h The number of entries into the shock zone was significantly higher in NfixiNestin (red) mice on days 4 and 5 of the APA task compared to NfixControl mice (black). i Total time spent in the shock zone was significantly longer for NfixiNestin (red) mice on days 4 and 5 of the APA task compared to NfixControl mice (black). **p < 0.01, *p < 0.05. All graphs depict mean ± s.e.m; n = 21 mice per genotype in (di)

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