Table 1 Association of clinico-pathologic parameters of Her2neu positive intrinsic breast cancer (non-luminal) with Her2neu positive luminal breast cancers (luminal B like)
| Â | n (%) | P-value | ||
|---|---|---|---|---|
Her2neu positive Intrinsic subtype | Her2neu positive luminal breast cancers | Total | ||
Age (years)ab | 49.40 ± 11.649 | 54.63 ± 12.740 | 50.98 ± 12.577 | < 0.01 |
Age group (n = 801) | ||||
 ≤ 30 | 15 (3.9) | 22 (5.3) | 37 (4.6) | 0.645 |
 31–50 | 204 (53.3) | 216 (51.7) | 420 (52.4) | |
 51–70 | 148 (38.6) | 157 (37.6) | 305 (38.1) | |
 > 70 | 16 (4.2) | 23 (5.5) | 39 (4.9) | |
Tumor grade (n = 801) | ||||
 Grade 1 | 8 (2.1) | 43 (10.3) | 51 (6.4) | < 0.01 |
 Grade 2 | 204 (53.3) | 260 (62.2) | 464 (57.9) | |
 Grade 3 | 171 (44.6) | 115 (27.5) | 286 (35.7) | |
Ki67 meanab | 42.61 ± 21.653 | 21.653 ± 3.344 | 34.59 ± 23.375 | < 0.01 |
Ki67 index category (n = 801) | ||||
 < 15 | 28 (7.3) | 47 (11.2) | 75 (9.4) | < 0.01 |
 15–24 | 64 (16.7) | 110 (26.3) | 174 (21.7) | |
 25–44 | 118 (30.8) | 127 (245) | 245 (30.6) | |
 > 44 | 173 (45.2) | 134 (32.1) | 307 (38.3) | |
Size of tumorab | 37.84 ± 16.114 | 35.21 ± 15.189 | 36.11 ± 15.233 | 0.142 |
Tumor stage (n = 249) | ||||
 T1 | 14 (11.8) | 16 (12.3) | 30 (12) | 0.27 |
 T2 | 78 (65.5) | 95 (73.1) | 173 (69.5) | |
 T3 | 27 (22.7) | 19 (14.6) | 46 (18.5) | |
Nodal status (n = 250) | ||||
 Positive | 65 (54.2) | 77 (59.2) | 142 (56.8) | 0.419 |
 Negative | 55 (45.8) | 53 (40.8) | 108 (43.2) | |
N stage (n = 250) | ||||
 N0 | 55 (45.8) | 54 (41.5) | 109 (43.6) | 0.172 |
 N1 | 17 (14.2) | 28 (21.5) | 45 (18) | |
 N2 | 18 (15) | 26 (20) | 44 (17.6) | |
 N3 | 30 (25) | 22 (16.9) | 52 (20.8) | |
Laterality (n = 801) | ||||
 Left | 193 (50.4) | 203 (48.6) | 396 (49.4) | 0.605 |
 Right | 190 (49.6) | 215 (51.4) | 405 (50.6) | |
Lymphocytic infiltration (n = 250) | ||||
 Absent | 63 (52.5) | 81 (62.3) | 144 (57.6) | 0.218 |
 Moderate | 43 (35.8) | 40 (30.8) | 83 (33.2) | |
 Severe | 14 (11.7) | 9 (6.9) | 23 (9.2) | |
Insitu component (n = 249) | ||||
 Present | 69 (57.5) | 89 (69) | 158 (63.5) | 0.06 |
 Absent | 51 (42.5) | 40 (31) | 91 (36.5) | |
Lymphovascular invasion (n = 250) | ||||
 Present | 35 (29.2) | 47 (36.2) | 82 (32.8) | 0.24 |
 Absent | 85 (70.8) | 83 (63.8) | 168 (67.2) | |
Dermal lymphatic invasion (n = 250) | ||||
 Present | 15 (12.5) | 15 (11.5) | 30 (12) | 0.815 |
 Absent | 105 (87.5) | 115 (88.5) | 220 (88) | |
Pagetoid spread (n = 250) | ||||
 Present | 7 (5.8) | 4 (3.1) | 11 (4.4) | 0.288 |
 Absent | 113 (94.2) | 126 (96.9) | 239 (95.6) | |