Skip to main content

Advertisement

Table 1 Association of clinico-pathologic parameters of Her2neu positive intrinsic breast cancer (non-luminal) with Her2neu positive luminal breast cancers (luminal B like)

From: Clinical and prognostic profile of Her2neu positive (non-luminal) intrinsic breast cancer subtype: comparison with Her2neu positive luminal breast cancers

  n (%) P-value
Her2neu positive Intrinsic subtype Her2neu positive luminal breast cancers Total
Age (years)ab 49.40 ± 11.649 54.63 ± 12.740 50.98 ± 12.577 < 0.01
Age group (n = 801)
 ≤ 30 15 (3.9) 22 (5.3) 37 (4.6) 0.645
 31–50 204 (53.3) 216 (51.7) 420 (52.4)
 51–70 148 (38.6) 157 (37.6) 305 (38.1)
 > 70 16 (4.2) 23 (5.5) 39 (4.9)
Tumor grade (n = 801)
 Grade 1 8 (2.1) 43 (10.3) 51 (6.4) < 0.01
 Grade 2 204 (53.3) 260 (62.2) 464 (57.9)
 Grade 3 171 (44.6) 115 (27.5) 286 (35.7)
Ki67 meanab 42.61 ± 21.653 21.653 ± 3.344 34.59 ± 23.375 < 0.01
Ki67 index category (n = 801)
 < 15 28 (7.3) 47 (11.2) 75 (9.4) < 0.01
 15–24 64 (16.7) 110 (26.3) 174 (21.7)
 25–44 118 (30.8) 127 (245) 245 (30.6)
 > 44 173 (45.2) 134 (32.1) 307 (38.3)
Size of tumorab 37.84 ± 16.114 35.21 ± 15.189 36.11 ± 15.233 0.142
Tumor stage (n = 249)
 T1 14 (11.8) 16 (12.3) 30 (12) 0.27
 T2 78 (65.5) 95 (73.1) 173 (69.5)
 T3 27 (22.7) 19 (14.6) 46 (18.5)
Nodal status (n = 250)
 Positive 65 (54.2) 77 (59.2) 142 (56.8) 0.419
 Negative 55 (45.8) 53 (40.8) 108 (43.2)
N stage (n = 250)
 N0 55 (45.8) 54 (41.5) 109 (43.6) 0.172
 N1 17 (14.2) 28 (21.5) 45 (18)
 N2 18 (15) 26 (20) 44 (17.6)
 N3 30 (25) 22 (16.9) 52 (20.8)
Laterality (n = 801)
 Left 193 (50.4) 203 (48.6) 396 (49.4) 0.605
 Right 190 (49.6) 215 (51.4) 405 (50.6)
Lymphocytic infiltration (n = 250)
 Absent 63 (52.5) 81 (62.3) 144 (57.6) 0.218
 Moderate 43 (35.8) 40 (30.8) 83 (33.2)
 Severe 14 (11.7) 9 (6.9) 23 (9.2)
Insitu component (n = 249)
 Present 69 (57.5) 89 (69) 158 (63.5) 0.06
 Absent 51 (42.5) 40 (31) 91 (36.5)
Lymphovascular invasion (n = 250)
 Present 35 (29.2) 47 (36.2) 82 (32.8) 0.24
 Absent 85 (70.8) 83 (63.8) 168 (67.2)
Dermal lymphatic invasion (n = 250)
 Present 15 (12.5) 15 (11.5) 30 (12) 0.815
 Absent 105 (87.5) 115 (88.5) 220 (88)
Pagetoid spread (n = 250)
 Present 7 (5.8) 4 (3.1) 11 (4.4) 0.288
 Absent 113 (94.2) 126 (96.9) 239 (95.6)
  1. Chi Square applied
  2. aMean ± SD
  3. bIndependent t-Test