Analysis of amino acid motif of penicillin-binding proteins 1a, 2b, and 2x in invasive Streptococcus pneumoniae nonsusceptible to penicillin isolated from pediatric patients in Casablanca, Morocco

Table 1 Origins, characteristics and pattern of resistance of the 30 pneumococcal isolates tested in this study

Strain no.	Sources	Age (year)	Year of isolation	Serotype	MIC (mg/L)			Resistance profile
Strain no.	Sources	Age (year)	Year of isolation	Serotype	PG	AMX	CRO	Resistance profile
Penicillin-susceptible
1	Blood	0.3	2014	1	0.008	0.003	0.008	Wild
2	CSF	0.3	2013	8	0.016	0.016	0.016	Wild
3	CSF	1	2012	9V	0.016	0.016	0.008	Wild
4	Blood	0.1	2011	2	0.016	0.016	0.008	Wild
5	PF	0.7	2010	6B	0.016	0.016	0.016	Wild
Penicillin-intermediate
6	Blood	0.1	2013	6B	0.125	0.06	0.004	PG, Ery, TE
7	CSF	0.4	2008	23F	0.125	0.032	0.064	PG
8	Blood	5	2008	6A	0.125	0.125	0.25	PG, Ery
9	Blood	4	2007	19F	0.125	0.25	0.25	PG, SXT, TE
10	Blood	3	2007	22F	0.25	0.064	0.032	PG
11	CSF	3	2012	14	0.5	0.25	0.25	PG, SXT
12	Pus	4	2011	19A	0.5	0.5	0.25	PG, Ery, TE
13	CSF	0.6	2013	6B	1	0.12	0.25	PG, Ery, TE
14	CSF	3	2010	6B	1	2	0.5	PG, Ery, SXT, TE
15	Blood	4	2014	14	1	1	0.5	PG, SXT, TE
Penicillin-resistant
16	Blood	0.5	2009	14	2	1	1	PG, SXT
17	CSF	0.5	2010	14	2	2	1	PG, SXT
18	CSF	0.3	2010	14	2	4	0.25	PG, SXT
19	PF	3	2011	14	2	1	0.5	PG, Ery, SXT, TE
20	CSF	1	2009	23F	2	4	0.5	PG, Ery, SXT, Chl, TE
21	Blood	0.3	2007	14	2	2	0.5	PG, SXT
22	Blood	3	2013	14	2	1	0.5	PG
23	Blood	0.6	2011	14	2	2	0.5	PG
24	Blood	1	2007	14	2	2	0.75	PG, SXT
25	Pus	0.8	2009	6B	2	2	0.5	PG, Ery, SXT, Chl, TE
26	Blood	0.5	2013	14	2	0.5	0.5	PG, SXT
27	Blood	0.4	2010	9V	2	4	0.5	PG, SXT
28	Blood	1	2009	14	2	2	0.5	PG, SXT
29	CSF	1.3	2010	14	2	2	0.5	PG, SXT
30	Blood	3	2011	14	2	1	0.25	PG, SXT

CSF cerebrospinal fluid, PF pleural fluid, MIC minimal inhibitory concentration, PG penicillin G, AMX amoxicillin, CRO ceftriaxone, SXT cotrimoxazole, TE tetracycline, Ery erythromycin, Chl chloramphenicol

ISSN: 1756-0500