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Table 2 PBP1a, PBP2b and PBP2x genetic profiles of the 30 pneumococcal isolates in Casablanca, Morocco

From: Analysis of amino acid motif of penicillin-binding proteins 1a, 2b, and 2x in invasive Streptococcus pneumoniae nonsusceptible to penicillin isolated from pediatric patients in Casablanca, Morocco

Strain no. Penicillin-binding protein motifs pbp profile
PBP1a PBP2b PBP2x plp1a plp2b plp2x
STMK (370–373) SRNVP (428–432) KTG (557−559) SVVK (385–388) SNNT (442–445) KTGTA (614–618) STMK (337–340) HSSN (395–397) LKSG (546–549)
Penicillin-susceptible
 1 −−−− −−−− −−−− −−−− −−−− −−−−− −−−− −−−− −−−− 5 11 7
 2 −−−− −−−−− −−− −−−− −−−− −−−−− −−−− −−−− −−−− 5 1 7
 3 −−−− −−−−− −−− −−−− −−−− −−−−− −−−− −−−− −−−− 5 2 7
 4 −−−− −−−−− −−− −−−− −−−− −−−−− −−−− −−−− −−−− 5 2 7
 5 −−−− −−−−− −−− −−−− −−−− −−−−− −−−− −−−− −−−− 5 2 7
Penicillin intermediate
 6 −−−− −−−−− −−− −−−− −−−A −−−−− −A−− −−−− V−−− 5 10 7
 7 −−−− −−−−− −−− −−−− −−−A −−−−− −A−− −−−− V−−− 4 5 9
 8 −A−− −−−−− −−− −−−− −−−A −−−−− −−−− −−−− −−−− 6 8 8
 9 −A−− −−−−T −−− −−−− −−−− −−−−− −−−− L−−− −−−− 3 2 4
 10 −−−− −−−−− −−− −−−− −−−A −−−−− −−−− −−−− −−−− 5 9 3
 11 −A−− −−−−T −−− −−−− −−−A −−−−− −A−− −−−− V−−− 1 4 6
 12 −A−− −−−−T −−− −−−− −−−A −−−−− −A−− −−−− V−−− 2 7 1
 13 −−−− −−−−− −−− −−−− −−−A −−−−− −A−− −−−− V−−− 5 3 2
 14 −A−− −−−−T −−− −−−− −−−A −−−−G −A−− −−−− V−−− 2 6 7
 15 −A−− −−−−T −−− −−−− −−−A −−−−− −A−− −−−− V−−− 1 4 6
Penicillin resistant
 16 −A−− −−−−T −−− −−−− −−−A −−−−− −A−− −−−− V−−− 2 4 6
 17 −A−− −−−−T −−− −−−− −−−A −−−−− −A−− −−−− V−−− 2 4 6
 18 −A−− −−−−T −−− −−−− −−−A −−−−G −A−− −−−− V−−− 1 8 5
 19 −A−− −−−−T −−− −−−− −−−A −−−−− −A−− −−−− V−−− 2 4 10
 20 −A−− −−−−T −−− −−−− −−−A −−−−− −A−− −−−− V−−− 1 4 6
 21 −A−− −−−−T −−− −−−− −−−A −−−−− −A−− −−−− V−−− 2 4 1
 22 −A−− −−−−T −−− −−−− −−−A −−−−− −A−− −−−− V−−− 1 4 5
 23 −A−− −−−−T −−− −−−− −−−A −−−−− −A−− −−−− V−−− 2 2 2
 24 −A−− −−−−T −−− −−−− −−−A −−−−− −A−− −−−− V−−− 2 4 7
 25 −A−− −−−−T −−− −−−− −−−A −−−−− −A−− −−−− V−−− 2 6 7
 26 −A−− −−−−T −−− −−−− −−−A −−−−− −A−− −−−− V−−− 1 4 6
 27 −A−− −−−−T −−− −−−− −−−A −−−−− −A−− −−−− V−−− 1 6 6
 28 −A−− −−−−T −−− −−−− −−−A −−−−− −A−− −−−− V−−− 1 4 1
 29 −A−− −−−−T −−− −−−− −−−A −−−−− −A−− −−−− V−−− 2 4 6
 30 −A−− −−−−T −−− −−−− −−−A −−−−− −A−− −−−− V−−− 1 1 1
  1. S: serine, T: threonine, M: methionine, K: lysine, R: arginine, N asparagine, V valine, P proline, G glycine, A alanine, H histidine, L leucine, PBP penicillin-binding protein