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Table 2 PBP1a, PBP2b and PBP2x genetic profiles of the 30 pneumococcal isolates in Casablanca, Morocco

From: Analysis of amino acid motif of penicillin-binding proteins 1a, 2b, and 2x in invasive Streptococcus pneumoniae nonsusceptible to penicillin isolated from pediatric patients in Casablanca, Morocco

Strain no.

Penicillin-binding protein motifs

pbp profile

PBP1a

PBP2b

PBP2x

plp1a

plp2b

plp2x

STMK (370–373)

SRNVP (428–432)

KTG (557−559)

SVVK (385–388)

SNNT (442–445)

KTGTA (614–618)

STMK (337–340)

HSSN (395–397)

LKSG (546–549)

Penicillin-susceptible

 1

−−−−

−−−−

−−−−

−−−−

−−−−

−−−−−

−−−−

−−−−

−−−−

5

11

7

 2

−−−−

−−−−−

−−−

−−−−

−−−−

−−−−−

−−−−

−−−−

−−−−

5

1

7

 3

−−−−

−−−−−

−−−

−−−−

−−−−

−−−−−

−−−−

−−−−

−−−−

5

2

7

 4

−−−−

−−−−−

−−−

−−−−

−−−−

−−−−−

−−−−

−−−−

−−−−

5

2

7

 5

−−−−

−−−−−

−−−

−−−−

−−−−

−−−−−

−−−−

−−−−

−−−−

5

2

7

Penicillin intermediate

 6

−−−−

−−−−−

−−−

−−−−

−−−A

−−−−−

−A−−

−−−−

V−−−

5

10

7

 7

−−−−

−−−−−

−−−

−−−−

−−−A

−−−−−

−A−−

−−−−

V−−−

4

5

9

 8

−A−−

−−−−−

−−−

−−−−

−−−A

−−−−−

−−−−

−−−−

−−−−

6

8

8

 9

−A−−

−−−−T

−−−

−−−−

−−−−

−−−−−

−−−−

L−−−

−−−−

3

2

4

 10

−−−−

−−−−−

−−−

−−−−

−−−A

−−−−−

−−−−

−−−−

−−−−

5

9

3

 11

−A−−

−−−−T

−−−

−−−−

−−−A

−−−−−

−A−−

−−−−

V−−−

1

4

6

 12

−A−−

−−−−T

−−−

−−−−

−−−A

−−−−−

−A−−

−−−−

V−−−

2

7

1

 13

−−−−

−−−−−

−−−

−−−−

−−−A

−−−−−

−A−−

−−−−

V−−−

5

3

2

 14

−A−−

−−−−T

−−−

−−−−

−−−A

−−−−G

−A−−

−−−−

V−−−

2

6

7

 15

−A−−

−−−−T

−−−

−−−−

−−−A

−−−−−

−A−−

−−−−

V−−−

1

4

6

Penicillin resistant

 16

−A−−

−−−−T

−−−

−−−−

−−−A

−−−−−

−A−−

−−−−

V−−−

2

4

6

 17

−A−−

−−−−T

−−−

−−−−

−−−A

−−−−−

−A−−

−−−−

V−−−

2

4

6

 18

−A−−

−−−−T

−−−

−−−−

−−−A

−−−−G

−A−−

−−−−

V−−−

1

8

5

 19

−A−−

−−−−T

−−−

−−−−

−−−A

−−−−−

−A−−

−−−−

V−−−

2

4

10

 20

−A−−

−−−−T

−−−

−−−−

−−−A

−−−−−

−A−−

−−−−

V−−−

1

4

6

 21

−A−−

−−−−T

−−−

−−−−

−−−A

−−−−−

−A−−

−−−−

V−−−

2

4

1

 22

−A−−

−−−−T

−−−

−−−−

−−−A

−−−−−

−A−−

−−−−

V−−−

1

4

5

 23

−A−−

−−−−T

−−−

−−−−

−−−A

−−−−−

−A−−

−−−−

V−−−

2

2

2

 24

−A−−

−−−−T

−−−

−−−−

−−−A

−−−−−

−A−−

−−−−

V−−−

2

4

7

 25

−A−−

−−−−T

−−−

−−−−

−−−A

−−−−−

−A−−

−−−−

V−−−

2

6

7

 26

−A−−

−−−−T

−−−

−−−−

−−−A

−−−−−

−A−−

−−−−

V−−−

1

4

6

 27

−A−−

−−−−T

−−−

−−−−

−−−A

−−−−−

−A−−

−−−−

V−−−

1

6

6

 28

−A−−

−−−−T

−−−

−−−−

−−−A

−−−−−

−A−−

−−−−

V−−−

1

4

1

 29

−A−−

−−−−T

−−−

−−−−

−−−A

−−−−−

−A−−

−−−−

V−−−

2

4

6

 30

−A−−

−−−−T

−−−

−−−−

−−−A

−−−−−

−A−−

−−−−

V−−−

1

1

1

  1. S: serine, T: threonine, M: methionine, K: lysine, R: arginine, N asparagine, V valine, P proline, G glycine, A alanine, H histidine, L leucine, PBP penicillin-binding protein