Skip to main content

Table 1 Inclusion and exclusion criteria

From: Transcranial magnetic stimulation intervention in Alzheimer’s disease: a research proposal for a randomized controlled trial

Inclusion criteria Exclusion criteria
Mini Mental State Examination (MMSE) [29] score between 20 and 26 Lack of knowledge of Spanish or Catalan
Global Deterioration Scale (GDS) [30] score of 3 or 4 Less than 4 years of schooling
Functional independence for basic daily life activities (part B of the Blessed Scale) [31] score equal to 0 Intellectual deficiency (Premorbid IQ, vocabulary, less than 85)
Rosen Ischemia Scale less or equal to 4 [32] No controlled medical conditions or severe mental disorders that may affect the central nervous system, including signs of increased intracranial pressure or intracranial lesions
Able to read and write Not controlled medical conditions that may cause emergencies or convulsions (e.g.: vascular risk, cardiac malformations or arrhythmias, asthma, etc.)
Stable medical and pharmacological condition during the 3 months immediately before the start of the study Medical history of convulsions, previous diagnosis of epilepsy, previous registry of abnormal electroencephalogram (EEG) or family history of epilepsy
Computerized tomography scan and magnetic resonance imaging (MRI) in the 12 months prior to the selection, compatible with the diagnosis of probable AD in the subjects diagnosed Severe hearing problems or ringing in the ears (tinnitus)
Absence of clinically significant anomalies in the medical history or clinical laboratory results during the selection Severe loss of visual acuity
Screening analyses within normal range to detect and exclude other causes of dementia in the 12 months previous to selection. Laboratory values considered are as follows: complete blood count, thyroid hormones (TSH), T4, folic acid, vitamin B12, albumin, transaminase alanine (ALT), aminotransferase aspartate (AST), gamma-glutamic transferase (GGT), sodium, potassium, urea, creatinine, and glucose while fasting Moderate or severe depression defined as a score > 11 in the Geriatric Depression Scale (GDS) [33]
Being treated by Acetylcholinesterase Inhibitors Presence of tremors or lack of motor control of the dominant upper limb
Willingness to undergo MRI scan Being under pharmacological treatment with medications indicated in the security TMS guidelines [34]
Signed consent form, previously approved by the Institutional Review Board of the Consorci Sanitari de Terrassa Drug or alcohol consumption or history of abuse in the 24 months prior to the study
  Implants of metal pieces in the head (excluding dental implants)
  Any of the following medical devices: pacemaker, implanted medication pumps, vagal nerve stimulators, deep cerebral stimulators, transcutaneous electrical stimulation units, ventriculo-peritoneal derivations, titanium plates, cochlear implants, aneurysm clips, etc.