Table 2 Outcome measures

Primary outcome measures

Memory

• Logical Memory, Wechsler Memory Scale IV (WMS-IV) [48]

• International Shopping List Task

• One Card Learning Task of the neurocognitive computerized battery CogState [49, 50]

Attention

• Identification Task of CogState computerized battery [49, 50]

• Direct digits of the Wechsler Adult Intelligence Scale IV (WAIS-IV) [51]

Working memory

• Ad hoc computerized Zero and One-Back task and the subtest of the backward digit span test of WAIS-IV [51]

Executive functions

• Five Digit Test [52]

• Ad hoc computerized Go/No-Go task

• Verbal fluency test (letters P-M-R and animals) [53]

Language

• Token Test [54]

• Short form of the Boston Naming Test [55]

Processing speed

• Detection Task of CogState computerized battery [49, 50]

General cognitive

• Alzheimer’s Disease Assessment Scale – cognitive subscale (ADAS-Cog) [56]

Secondary outcome measures

Functional connectivity

• Assessed one time after 10 treatment sessions, through the registry of brain activity in resting state MRI

Functional capacity

• Functional Assessment Questionnaire (FAQ) [57]

• UCSD Performance-Based Skills Assessment (UPSA) [58]

Mood changes (depression)

• Hospital Anxiety and Depression scale (HAD) [59]

• Geriatric Depression Scale (GDS) [33]

Activities of daily living

• Alzheimer’s Disease Assessment Scale – activities of daily living subscale (ADAS-ADL) [56]

Modulatory outcome measures

Premorbid intellectual level

• “Word Accentuation Test” (a Spanish language test) [60]

Cognitive reserve

• Cognitive Reserve Questionnaire [61]

ApoE (ε4, ε2)

• Genetic analysis